American Journal of Epidemiology Advance Access originally published online on March 6, 2009
American Journal of Epidemiology 2009 169(8):927-936; doi:10.1093/aje/kwp007
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ORIGINAL CONTRIBUTIONS |
Overweight and Obesity Over the Adult Life Course and Incident Mobility Limitation in Older Adults
The Health, Aging and Body Composition Study
Correspondence to Dr. Denise K. Houston, Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157-1207 (e-mail: dhouston{at}wfubmc.edu).
Received for publication September 29, 2008. Accepted for publication January 6, 2009.
Obesity in middle and old age predicts mobility limitation; however, the cumulative effect of overweight and/or obesity over the adult life course is unknown. The association between overweight and/or obesity in young, middle, and late adulthood and its cumulative effect on incident mobility limitation was examined among community-dwelling US adults aged 70–79 years at baseline (1997–1998) in the Health, Aging and Body Composition Study (n = 2,845). Body mass index was calculated by using recalled weight at ages 25 and 50 years and measured weight at ages 70–79 years. Mobility limitation (difficulty walking 1/4 mile (0.4 km) or climbing 10 steps) was assessed semiannually over 7 years of follow-up and was reported by 43.0% of men and 53.7% of women. Men and women who were overweight or obese at all 3 time points had an increased risk of mobility limitation (hazard ratio = 1.61, 95% confidence interval: 1.25, 2.06 and hazard ratio = 2.85, 95% confidence interval: 2.15, 3.78, respectively) compared with those who were normal weight throughout. Furthermore, there was a significant graded response (P < 0.0001) on risk of mobility limitation for the cumulative effect of obesity in men and overweight and/or obesity in women. Onset of overweight and obesity in earlier life contributes to an increased risk of mobility limitation in old age.
aged; mobility limitation; obesity; overweight
Abbreviations: BMI, body mass index; Health ABC, Health, Aging and Body Composition
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