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American Journal of Epidemiology Advance Access originally published online on February 18, 2009
American Journal of Epidemiology 2009 169(7):837-847; doi:10.1093/aje/kwn395
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American Journal of Epidemiology © The Author 2009. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

ORIGINAL CONTRIBUTIONS

Association of Hip Circumference With Incident Diabetes and Coronary Heart Disease

The Atherosclerosis Risk in Communities Study

Emily D. Parker, Mark A. Pereira, June Stevens and Aaron R. Folsom

Correspondence to Dr. Emily D. Parker, HealthPartners Research Foundation, Mail Stop 21111R, 8170 33rd Avenue South, PO Box 1524, Minneapolis, MN 55406-1524 (e-mail: emily.d.parker{at}healthpartners.com).

Received for publication December 3, 2007. Accepted for publication November 20, 2008.

When waist circumference is taken into account, larger hip circumference is associated with reduced risk factors for diabetes and cardiovascular disease. The authors investigated the prospective association of hip circumference with type 2 diabetes and coronary heart disease (CHD) incidence in a biracial cohort of men and women in 4 US communities. A total of 10,767 participants from the Atherosclerosis Risk in Communities (ARIC) study were followed from 1987 to 1998. Hip and waist circumferences and body mass index (BMI) were modeled separately and mutually in association with incident diabetes and CHD by using proportional hazards regression. After adjustment for age, race, sex, and clinical center, hip circumference was positively associated with incident diabetes. However, after further controlling for waist circumference, BMI, and confounding variables, successive quintiles of hip circumference were associated with a statistically significant reduced hazard of incident diabetes (hazard ratios = 1.00, 0.79, 0.60, 0.44, 0.41). Similarly, successive quintiles of hip circumference were associated with a statistically significant reduced hazard of CHD after controlling for waist circumference, BMI, and confounding variables (hazard ratios = 1.00, 0.92, 0.75, 0.63, 0.50). Although excess adiposity is a general risk factor for diabetes and CHD, for a given BMI and waist circumference, greater hip circumference appears to lessen the risk of diabetes and CHD.

adiposity; anthropometry; coronary disease; diabetes mellitus

Abbreviations: ARIC, Atherosclerosis Risk in Communities; BMI, body mass index; CHD, coronary heart disease


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