American Journal of Epidemiology Advance Access originally published online on September 12, 2008
American Journal of Epidemiology 2008 168(9):1024-1034; doi:10.1093/aje/kwn212
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ORIGINAL CONTRIBUTIONS |
Intakes of Fruit, Vegetables, and Specific Botanical Groups in Relation to Lung Cancer Risk in the NIH-AARP Diet and Health Study
Correspondence to Dr. Margaret E. Wright, Department of Pathology (MC 847), College of Medicine, University of Illinois at Chicago, 840 South Wood Street, Room 130, Chicago, IL 60612 (e-mail: mewright{at}uic.edu).
Received for publication November 16, 2007. Accepted for publication June 13, 2008.
Increased fruit and vegetable consumption may protect against lung cancer, although epidemiologic findings are inconclusive. The authors prospectively examined associations between lung cancer risk and intakes of fruit, vegetables, and botanical subgroups in 472,081 participants aged 50–71 years in the National Institutes of Health (NIH)-AARP Diet and Health Study. Diet was assessed at baseline (1995–1996) with a 124-item dietary questionnaire. A total of 6,035 incident lung cancer cases were identified between 1995 and 2003. Total fruit and vegetable intake was unrelated to lung cancer risk in both men and women. Higher consumption of several botanical subgroups, however, was significantly inversely associated with risk, but only in men. For example, the relative risks of lung cancer among men in the highest versus lowest quintiles of intake of rosaceae, convolvulaceae, and umbelliferae were 0.82 (95% confidence interval (CI): 0.73, 0.91), 0.86 (95% CI: 0.75, 0.96), and 0.86 (95% CI: 0.78, 0.96), respectively; corresponding relative risks in women were 0.97 (95% CI: 0.85, 1.12), 0.95 (95% CI: 0.83, 1.09), and 0.92 (95% CI: 0.80, 1.06). These results provide support for a protective role of specific botanical subgroups of fruits and vegetables in lung cancer prevention in men, although the findings could also be due to residual confounding by smoking or chance.
cohort studies; fruit; lung neoplasms; vegetables
Abbreviations: CI, confidence interval; ICD-O-3, International Classification of Diseases for Oncology, Third Edition; NIH, National Institutes of Health; RR, relative risk
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. A. Quandt, H. Chen, R. A. Bell, M. R. Savoca, A. M. Anderson, X. Leng, T. Kohrman, G. H. Gilbert, and T. A. Arcury Food Avoidance and Food Modification Practices of Older Rural Adults: Association With Oral Health Status and Implications for Service Provision Gerontologist, July 2, 2009; (2009) gnp096v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M George, Y. Park, M. F Leitzmann, N. D Freedman, E. C Dowling, J. Reedy, A. Schatzkin, A. Hollenbeck, and A. F Subar Fruit and vegetable intake and risk of cancer: a prospective cohort study Am. J. Clinical Nutrition, January 1, 2009; 89(1): 347 - 353. [Abstract] [Full Text] [PDF]
|
|