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American Journal of Epidemiology Advance Access originally published online on October 25, 2008
American Journal of Epidemiology 2008 168(11):1333-1338; doi:10.1093/aje/kwn278
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American Journal of Epidemiology © The Author 2008. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

PRACTICE OF EPIDEMIOLOGY

A Simple Approach for Fitting Linear Relative Rate Models in SAS

David B. Richardson

Correspondence to Dr. David Richardson, Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 (e-mail: david.richardson{at}unc.edu).

Received for publication March 27, 2008. Accepted for publication August 4, 2008.

The linear relative rate model has been employed in epidemiologic analyses of a variety of environmental and occupational exposures. In contrast to an exponential rate model, the linear relative rate model implies that the excess relative rate of disease changes in an additive fashion with exposure. The linear relative rate model may be fitted using EPICURE (HiroSoft International Corporation, Seattle, Washington), a specialized statistical software package widely used for such analyses. In this paper, the author presents a simple approach to fitting the linear relative rate model to epidemiologic data using PROC NLMIXED in the SAS statistical software package (SAS Institute Inc., Cary, North Carolina). This approach is illustrated via analyses of data from a study of mortality in a cohort of South Carolina asbestos textile workers (1940–2001).

cohort analysis; dose-response function; epidemiologic methods; linear trend; models, statistical; Poisson regression; software


Abbreviations: ICD, International Classification of Diseases


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