Skip Navigation


American Journal of Epidemiology Advance Access originally published online on February 27, 2008
American Journal of Epidemiology 2008 167(9):1050-1058; doi:10.1093/aje/kwm400
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
167/9/1050    most recent
kwm400v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (7)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Shrubsole, M. J.
Right arrow Articles by Zheng, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shrubsole, M. J.
Right arrow Articles by Zheng, W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology © The Author 2008. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

ORIGINAL CONTRIBUTIONS

Alcohol Drinking, Cigarette Smoking, and Risk of Colorectal Adenomatous and Hyperplastic Polyps

Martha J. Shrubsole1,2,3,4, Huiyun Wu4, Reid M. Ness3,4,5, Yu Shyr4, Walter E. Smalley1,3,4,5,6 and Wei Zheng1,2,3,4

1 Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN
2 Division of General Internal Medicine and Public Health, School of Medicine, Vanderbilt University, Nashville, TN
3 Geriatric Research Education and Clinical Center, Tennessee Valley Healthcare System, US Department of Veterans Affairs, Nashville, TN
4 Vanderbilt-Ingram Cancer Center, Nashville, TN
5 Division of Gastroenterology, School of Medicine, Vanderbilt University, Nashville, TN
6 Department of Preventive Medicine, School of Medicine, Vanderbilt University, Nashville, TN

Correspondence to Dr. Martha J. Shrubsole, Vanderbilt Epidemiology Center, 2525 West End Avenue, Suite 800, Nashville, TN 37203-1738 (e-mail: martha.shrubsole{at}vanderbilt.edu).

Received for publication June 28, 2007. Accepted for publication December 21, 2007.

The authors evaluated alcohol drinking and cigarette smoking in relation to risk of colorectal polyps in a Nashville, Tennessee, colonoscopy-based case-control study. In 2003–2005, cases with adenomatous polyps only (n = 639), hyperplastic polyps only (n = 294), and both types of polyps (n = 235) were compared with 1,773 polyp-free controls. Unordered polytomous logistic regression was used to calculate adjusted odds ratios and 95% confidence intervals. Consumption of at least five alcoholic drinks per week was not strongly associated with development of polyps. Odds ratios for all polyp types were increased for dose, duration, and pack-years of cigarette smoking and were stronger for hyperplastic polyps than for adenoma. Compared with never smoking, dose-response relations were particularly strong for current smoking and duration; for ≥35 years of smoking, odds ratios were 1.9 (95% confidence interval (CI): 1.4, 2.5) for adenomatous polyps only, 5.0 (95% CI: 3.3, 7.3) for hyperplastic polyps only, and 6.9 (95% CI: 4.4, 11.1) for both types of polyps. Compared with current smoking, time since cessation was associated with substantially reduced odds; for ≥20 years since quitting, odds ratios were 0.4 (95% CI: 0.3, 0.6) for adenoma only, 0.2 (95% CI: 0.1, 0.3) for hyperplastic polyps only, and 0.2 (95% CI: 0.2, 0.4) for both polyp types. These findings support the adverse role of cigarette smoking in colorectal tumorigenesis and suggest that quitting smoking may substantially reduce the risk of colorectal polyps.

adenomatous polyps; alcohol drinking; colonic polyps; colorectal neoplasms; intestinal polyps; smoking

Abbreviations: CI, confidence interval; PLCO, Prostate, Lung, Colorectal, and Ovarian


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
K. Wallace, M. V. Grau, D. Ahnen, D. C. Snover, D. J. Robertson, D. Mahnke, J. Gui, E. L. Barry, R. W. Summers, G. McKeown-Eyssen, et al.
The Association of Lifestyle and Dietary Factors with the Risk for Serrated Polyps of the Colorectum
Cancer Epidemiol. Biomarkers Prev., August 1, 2009; 18(8): 2310 - 2317.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.