Skip Navigation


American Journal of Epidemiology Advance Access originally published online on January 23, 2008
American Journal of Epidemiology 2008 167(7):839-846; doi:10.1093/aje/kwm381
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
167/7/839    most recent
kwm381v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Kubo, A.
Right arrow Articles by Corley, D. A.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kubo, A.
Right arrow Articles by Corley, D. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology © The Author 2008. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

ORIGINAL CONTRIBUTIONS

Dietary Patterns and the Risk of Barrett's Esophagus

Ai Kubo1, T. R. Levin1, Gladys Block2, Gregory J. Rumore1, Charles P. Quesenberry, Jr1, Patricia Buffler2 and Douglas A. Corley1,3

1 Division of Research, Kaiser Permanente Northern California, Oakland, CA
2 Department of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, CA
3 Department of Medicine and Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA

Correspondence to Dr. Ai Kubo, Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612 (e-mail: ai.kubo{at}kp.org).

Received for publication July 28, 2007. Accepted for publication December 4, 2007.

The objective of this study was to examine the associations between dietary patterns and the risk of Barrett's esophagus, a precursor to esophageal adenocarcinoma. The authors conducted a case-control study within the Kaiser Permanente Northern California population between 2002 and 2005. Patients with a new diagnosis of Barrett's esophagus (n = 296 cases) were matched to persons with gastroesophageal reflux disease (n = 308) without Barrett's esophagus and to population controls (n = 309). Dietary information was obtained from a validated, 110-item food frequency questionnaire. A principal component analysis was used to identify major dietary patterns. Two major dietary patterns were "Western" (high in fast food and meat) and "health-conscious" (high in fruits, vegetables, and nonfried fish). When cases and population controls were compared, strong adherence to the health-conscious dietary pattern was inversely associated with Barrett's esophagus (odds ratio = 0.35, 95% confidence interval: 0.20, 0.64; fourth vs. first quartile comparison). In contrast, data suggested an adverse effect of the Western dietary pattern on the risk of Barrett's esophagus, although no dose-effect relation was found. Results suggest strong associations between a diet rich in fruits and vegetables and the risk of Barrett's esophagus.

Barrett esophagus; diet; esophageal neoplasms; factor analysis, statistical; food habits

Abbreviations: CI, confidence interval; GERD, gastroesophageal reflux disease; OR, odds ratio


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.