Skip Navigation


American Journal of Epidemiology Advance Access originally published online on April 4, 2008
American Journal of Epidemiology 2008 167(11):1312-1320; doi:10.1093/aje/kwn069
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
167/11/1312    most recent
kwn069v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Chajès, V.
Right arrow Articles by Clavel-Chapelon, F.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chajès, V.
Right arrow Articles by Clavel-Chapelon, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology © The Author 2008. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

ORIGINAL CONTRIBUTIONS

Association between Serum trans-Monounsaturated Fatty Acids and Breast Cancer Risk in the E3N-EPIC Study

Véronique Chajès1, Anne C. M. Thiébaut2, Maxime Rotival2, Estelle Gauthier2, Virginie Maillard1, Marie-Christine Boutron-Ruault2, Virginie Joulin1, Gilbert M. Lenoir1 and Françoise Clavel-Chapelon2

1 Centre National de la Recherche Scientifique, FRE 2939, Institut Gustave Roussy, Villejuif, France
2 Institut National de la Santé et de la Recherche Médicale, ERI-20, EA4045, and Institut Gustave Roussy, Villejuif, France

Correspondence to Dr. Véronique Chajès, Centre National de la Recherche Scientifique, FRE 2939, Institut Gustave Roussy, 29, rue Camille Desmoulins, 94805 Villejuif, France (e-mail: chajes{at}igr.fr).

Received for publication July 5, 2007. Accepted for publication February 19, 2008.

The authors assessed the association between serum phospholipid fatty acids as biomarkers of fatty acid intake and breast cancer risk among women in the E3N Study (1989–2002), the French component of the European Prospective Investigation into Cancer and Nutrition. During an average of 7 years of follow-up, 363 cases of incident invasive breast cancer were documented among 19,934 women who, at baseline (1995–1998), had completed a diet history questionnaire and provided serum samples. Controls were randomly matched to cases by age, menopausal status at blood collection, fasting status at blood collection, date, and collection center. Serum phospholipid fatty acid composition was assessed by gas chromatography. Adjusted odds ratios for risk of breast cancer with increasing levels of fatty acids were calculated using conditional logistic regression. An increased risk of breast cancer was associated with increasing levels of the trans-monounsaturated fatty acids palmitoleic acid and elaidic acid (highest quintile vs. lowest: odds ratio = 1.75, 95% confidence interval: 1.08, 2.83; p-trend = 0.018). cis-Monounsaturated fatty acids were unrelated to breast cancer risk. A high serum level of trans-monounsaturated fatty acids, presumably reflecting a high intake of industrially processed foods, is probably one factor contributing to increased risk of invasive breast cancer in women.

breast neoplasms; diet; fatty acids; trans fatty acids

Abbreviations: CI, confidence interval; EPIC, European Prospective Investigation into Cancer and Nutrition; MUFA, monounsaturated fatty acid; OR, odds ratio; PUFA, polyunsaturated fatty acid; SI, saturation index


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.