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American Journal of Epidemiology Advance Access originally published online on July 5, 2007
American Journal of Epidemiology 2007 166(5):552-560; doi:10.1093/aje/kwm119
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American Journal of Epidemiology © The Author 2007. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

ORIGINAL CONTRIBUTIONS

Plasma Fluorescent Oxidation Products as Potential Markers of Oxidative Stress for Epidemiologic Studies

Tianying Wu1, Walter C. Willett1,2,3, Nader Rifai4 and Eric B. Rimm1,2,3

1 Department of Nutrition, Harvard School of Public Health, Boston, MA
2 Department of Epidemiology, Harvard School of Public Health, Boston, MA
3 Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA
4 Department of Laboratory Medicine, Children's Hospital and Harvard Medical School, Boston, MA

Correspondence to Dr. Tianying Wu, Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115 (e-mail: hptwu{at}channing.harvard.edu; tianying.wu{at}uc.edu).

Received for publication June 20, 2006. Accepted for publication March 9, 2007.

Currently lacking are stable and easily measured biomarkers that can reflect oxidative stress in humans. Fluorescent oxidation products may fulfill all three of these criteria. Fasting plasma levels of fluorescent oxidation products were measured in 286 controls in a study of coronary heart disease among US men aged 47–81 years; the study concluded in 2006. Other biomarkers in plasma were also measured, and cardiovascular risk factors such as smoking, hypertension, age, and physical activity were assessed by questionnaire. Indicators of oxidative stress, including smoking, hypertension, and reduced renal function, were associated with greater fluorescent oxidation products in both age- and multivariate-adjusted analyses (for each, p for trend < 0.01). In a multivariate-adjusted analysis, levels of fluorescent oxidation products were 45% higher in current smokers than in never smokers and 61% higher in men who smoked more than 25 cigarettes/day versus 1–4 cigarettes/day. The levels of this marker were 17% higher in hypertensive men than in normotensive men and 20% higher in men in the lowest versus the highest quartile of glomerular filtration rate. Levels were 57% higher in men with both hypertension and reduced renal function than in men with neither. The association of fluorescent oxidation products with several indicators of oxidative stress suggests that this measure could be a useful global marker of oxidative stress for large epidemiologic studies.

biological markers; coronary disease; epidemiologic studies; fluorescence; oxidation-reduction; oxidative stress; plasma; risk factors

Abbreviations: CHD, coronary heart disease; FI, fluorescent intensity; GFR, glomerular filtration rate


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R. Meerwaldt, T. Links, C. Zeebregts, and A. Smit
RE: "PLASMA FLUORESCENT OXIDATION PRODUCTS AS POTENTIAL MARKERS OF OXIDATIVE STRESS FOR EPIDEMIOLOGIC STUDIES"
Am. J. Epidemiol., March 15, 2008; 167(6): 756 - 757.
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