Skip Navigation


American Journal of Epidemiology Advance Access originally published online on September 7, 2007
American Journal of Epidemiology 2007 166(12):1420-1430; doi:10.1093/aje/kwm242
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
166/12/1420    most recent
kwm242v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (9)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Xu, W. H.
Right arrow Articles by Shu, X. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xu, W. H.
Right arrow Articles by Shu, X. O.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology © The Author 2007. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

ORIGINAL CONTRIBUTIONS

Interaction of Soy Food and Tea Consumption with CYP19A1 Genetic Polymorphisms in the Development of Endometrial Cancer

Wang Hong Xu1, Qi Dai2, Yong Bing Xiang1, Ji Rong Long2, Zhi Xian Ruan1, Jia Rong Cheng1, Wei Zheng2 and Xiao Ou Shu2

1 Department of Epidemiology, Shanghai Cancer Institute and Cancer Institute of Shanghai Jiao Tong University, Shanghai, People's Republic of China
2 Vanderbilt Epidemiology Center, Vanderbilt Institute of Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN

Correspondence to Dr. Xiao Ou Shu, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 600, Nashville, TN 37203-1738 (e-mail: Xiao-ou.shu{at}vanderbilt.edu).

Received for publication April 5, 2007. Accepted for publication July 27, 2007.

Certain polyphenols inhibit the activity of aromatase, a critical enzyme in estrogen synthesis that is coded by the CYP19A1 gene. Consumption of polyphenol-rich foods and beverages, thus, may interact with CYP19A1 genetic polymorphisms in the development of endometrial cancer. The authors tested this hypothesis in the Shanghai Endometrial Cancer Study (1997–2003), a population-based case-control study of 1,204 endometrial cancer cases and 1,212 controls. Dietary information was obtained by use of a validated food frequency questionnaire. Genotypes of CYP19A1 at rs28566535, rs1065779, rs752760, rs700519, and rs1870050 were available for 1,042 cases and 1,035 controls. Unconditional logistic regression models were used to calculate odds ratios and their 95% confidence intervals after adjustment for potential confounding factors. Higher intake of soy foods and tea consumption were both inversely associated with the risk of endometrial cancer, with odds ratios of 0.8 (95% confidence interval: 0.6, 1.0) for the highest versus the lowest tertiles of intake of soy and 0.8 (95% confidence interval: 06, 0.9) for ever tea consumption. The association of single nucleotide polymorphisms rs1065779, rs752760, and rs1870050 with endometrial cancer was modified by tea consumption (pinteraction < 0.05) but not by soy isoflavone intake. The authors' findings suggest that tea polyphenols may modify the effect of CYP19A1 genetic polymorphisms on the development of endometrial cancer.

aromatase; endometrial neoplasms; polymorphism, genetic; soy foods; tea

Abbreviations: QC, quality control; SECS, Shanghai Endometrial Cancer Study; SNP, single nucleotide polymorphism


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Prevention ResearchHome page
E. P. Moiseeva and M. M. Manson
Dietary Chemopreventive Phytochemicals: Too Little or Too Much?
Cancer Prevention Research, July 1, 2009; 2(7): 611 - 616.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
A. Beeghly-Fadiel, Y.-B. Xiang, S. L. Deming, J.-R. Long, W.-H. Xu, Q. Cai, W. Zheng, and X. O. Shu
No Association between Matrix Metalloproteinase (MMP)-1, MMP-3, and MMP-7 SNPs and Endometrial Cancer Risk
Cancer Epidemiol. Biomarkers Prev., June 1, 2009; 18(6): 1925 - 1928.
[Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
V. W. Setiawan, J. A. Doherty, X.-o. Shu, M. R. Akbari, C. Chen, I. De Vivo, A. DeMichele, M. Garcia-Closas, M. T. Goodman, C. A. Haiman, et al.
Two Estrogen-Related Variants in CYP19A1 and Endometrial Cancer Risk: A Pooled Analysis in the Epidemiology of Endometrial Cancer Consortium
Cancer Epidemiol. Biomarkers Prev., January 1, 2009; 18(1): 242 - 247.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. L. Deming, W. Zheng, W.-H. Xu, Q. Cai, Z. Ruan, Y.-B. Xiang, and X.-O. Shu
UGT1A1 Genetic Polymorphisms, Endogenous Estrogen Exposure, Soy Food Intake, and Endometrial Cancer Risk
Cancer Epidemiol. Biomarkers Prev., March 1, 2008; 17(3): 563 - 570.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.