American Journal of Epidemiology Advance Access originally published online on August 30, 2007
American Journal of Epidemiology 2007 166(10):1159-1173; doi:10.1093/aje/kwm193
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ORIGINAL CONTRIBUTIONS |
Oral Health and Risk of Squamous Cell Carcinoma of the Head and Neck and Esophagus: Results of Two Multicentric Case-Control Studies
1 International Agency for Research on Cancer, Lyon, France
2 Department of Epidemiology, School of Public Health, University of São Paulo, São Paulo, Brazil
3 Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
4 Institute of Carcinogenesis, Cancer Research Center, Moscow, Russia
5 Associação de Combate ao Câncer em Goiás, Goiânia, Brazil
6 National School of Public Health, Oswaldo Cruz Foundation Ministry of Health, Rio de Janeiro, Brazil
7 Angel H. Roffo Oncology Institute, University of Buenos Aires, Buenos Aires, Argentina
8 Departamento de Clinica Medica, Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas, Brazil
9 Institute of Occupational Medicine, Lodz, Poland
10 Instituto Nacional de Oncologia y Radiobiologia, La Havana, Cuba
11 Institute of Hygiene, Public Health, Health Services, and Management, Bucharest, Romania
12 Oncology Unit, Hospital de Clinica de Porto Alegre, Porto Alegre, Brazil
13 Department of Epidemiology and Cancer Prevention, Cancer Center and M. Sklodowska-Curie Institute of Oncology, Warsaw, Poland
Correspondence to Dr. Paul Brennan, Genetic Epidemiology Group, Genetics and Epidemiology Cluster, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France (e-mail: brennan{at}iarc.fr).
Received for publication September 28, 2006. Accepted for publication May 31, 2007.
Poor oral health has been reported as a risk factor in the etiology of head and neck cancer. Data on oral health were ascertained as part of two multicenter case-control studies comprising 924 cases and 928 controls in central Europe and 2,286 cases and 1,824 controls in Latin America. Incident cases of squamous cell carcinoma of the head and neck (oral cavity, pharynx, larynx) and esophagus, as well as age (in quinquennia)- and sex frequency-matched controls, were enrolled from 1998 to 2003. Poor condition of the mouth (central Europe: odds ratio (OR) = 2.89, 95% confidence interval (CI): 1.74, 4.81; Latin America: OR = 1.89, 95% CI: 1.47, 2.42), lack of toothbrush use (Latin America: OR = 2.36, 95% CI: 1.28, 4.36), and daily mouthwash use (Latin America: OR = 3.40, 95% CI: 1.96, 5.89) emerged as risk factors for head and neck cancer, independent of tobacco use and alcohol consumption. Missing between six and 15 teeth was an independent risk factor for esophageal cancer (central Europe: OR = 2.84, 95% CI: 1.26, 6.41; Latin America: OR = 2.18, 95% CI: 1.04, 4.59). These results indicate that periodontal disease (as indicated by poor condition of the mouth and missing teeth) and daily mouthwash use may be independent causes of cancers of the head, neck, and esophagus.
dentition; dentures; esophageal neoplasms; gingivitis; head and neck neoplasms; mouthwashes; oral hygiene; periodontal diseases
Abbreviations: CI, confidence interval; OR, odds ratio
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. H. Lubin, M. Purdue, K. Kelsey, Z.-F. Zhang, D. Winn, Q. Wei, R. Talamini, N. Szeszenia-Dabrowska, E. M. Sturgis, E. Smith, et al. Total Exposure and Exposure Rate Effects for Alcohol and Smoking and Risk of Head and Neck Cancer: A Pooled Analysis of Case-Control Studies Am. J. Epidemiol., October 15, 2009; 170(8): 937 - 947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tezal, M. A. Sullivan, A. Hyland, J. R. Marshall, D. Stoler, M. E. Reid, T. R. Loree, N. R. Rigual, M. Merzianu, L. Hauck, et al. Chronic Periodontitis and the Incidence of Head and Neck Squamous Cell Carcinoma Cancer Epidemiol. Biomarkers Prev., September 1, 2009; 18(9): 2406 - 2412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Abnet, F. Kamangar, F. Islami, D. Nasrollahzadeh, P. Brennan, K. Aghcheli, S. Merat, A. Pourshams, H. A. Marjani, A. Ebadati, et al. Tooth Loss and Lack of Regular Oral Hygiene Are Associated with Higher Risk of Esophageal Squamous Cell Carcinoma Cancer Epidemiol. Biomarkers Prev., November 1, 2008; 17(11): 3062 - 3068. [Abstract] [Full Text] [PDF]
|
|