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American Journal of Epidemiology Advance Access originally published online on February 13, 2007
American Journal of Epidemiology 2007 165(9):993-997; doi:10.1093/aje/kwm033
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American Journal of Epidemiology Copyright © 2007 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.

Invited Commentary

Invited Commentary: Lipoproteins and Dementia—Is It the Apolipoprotein A-I?

Nikolaos Scarmeas1,2,3

1 Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY
2 Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY
3 Department of Neurology, Columbia University Medical Center, New York, NY

Correspondence to Dr. Nikolaos Scarmeas, Columbia University Medical Center, 622 West 168th Street, PH 19th Floor, New York, NY, 10032 (e-mail: ns257{at}columbia.edu).

Received for publication November 30, 2006. Accepted for publication December 8, 2006.

Because of the aging of the population, dementia has become a major public health problem. There has been growing evidence for a possible association between lipids and dementia. A large body of literature has demonstrated multiple hypothesized biologic links between lipids and neurodegenerative or other biologic pathways connected to dementing processes. However, the epidemiologic associations have been conflicting: dyslipidemia at middle age, but not in later life, seems to be associated with higher dementia risk in some but not all studies. Results from the Honolulu-Asia Aging Study reported by Saczynski et al. (Am J Epidemiol 2007;165:985–92) suggest that lipoprotein constituents, such as apolipoprotein A-I, a major component of the high density lipoprotein, may be more informative in enlightening the association between lipids and dementia. In this commentary, the epidemiology and biology of apolipoprotein A-I in relation to dementia is reviewed.

Alzheimer disease; apolipoproteins; dementia; lipids

Abbreviations: ApoA-I, apolipoprotein A-I; HDL, high density lipoprotein


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Related articles in Am. J. Epidemiol.:

The Relation between Apolipoprotein A-I and Dementia: The Honolulu-Asia Aging Study
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