Skip Navigation


American Journal of Epidemiology Advance Access originally published online on March 10, 2007
American Journal of Epidemiology 2007 165(9):1076-1087; doi:10.1093/aje/kwk115
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
165/9/1076    most recent
kwk115v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (20)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Harris, T. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harris, T. B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Copyright © 2007 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.

PRACTICE OF EPIDEMIOLOGY

Age, Gene/Environment Susceptibility–Reykjavik Study: Multidisciplinary Applied Phenomics

Tamara B. Harris1, Lenore J. Launer1, Gudny Eiriksdottir2, Olafur Kjartansson3, Palmi V. Jonsson4,5, Gunnar Sigurdsson5,6, Gudmundur Thorgeirsson5,7, Thor Aspelund2, Melissa E. Garcia1, Mary Frances Cotch8, Howard J. Hoffman9 and Vilmundur Gudnason2,5 for the Age, Gene/Environment Susceptibility–Reykjavik Study Investigators

1 Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD
2 Icelandic Heart Association, Kopavogur, Iceland
3 Department of Radiology, Landspitali University Hospital, Reykjavik, Iceland
4 Department of Geriatrics, Landspitali University Hospital, Reykjavik, Iceland
5 Faculty of Medicine, University of Iceland, Reykjavik, Iceland
6 Department of Endocrinology and Metabolism, Landspitali University Hospital, Reykjavik, Iceland
7 Department of Medicine, Landspitali University Hospital, Reykjavik, Iceland
8 Division of Epidemiology and Clinical Research, National Eye Institute, Bethesda, MD
9 Epidemiology and Biostatistics Program, National Institute of Deafness and Communication Disorders, Bethesda, MD

Correspondence to Dr. Tamara B. Harris or Dr. Lenore J. Launer, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Avenue, Suite 3C309, Bethesda, MD 20892-9205 (e-mail: Harris99{at}mail.nih.gov or LaunerL{at}mail.nih.gov) or Dr. Vilmundur Gudnason, Icelandic Heart Association, Holtasmara 1, 201 Kopavogur, Iceland (e-mail: v.gudnason{at}hjarta.is).

Received for publication April 14, 2006. Accepted for publication October 24, 2006.

In anticipation of the sequencing of the human genome and description of the human proteome, the Age, Gene/Environment Susceptibility–Reykjavik Study (AGES–Reykjavik) was initiated in 2002. AGES–Reykjavik was designed to examine risk factors, including genetic susceptibility and gene/environment interaction, in relation to disease and disability in old age. The study is multidisciplinary, providing detailed phenotypes related to the cardiovascular, neurocognitive (including sensory), and musculoskeletal systems, and to body composition and metabolic regulation. Relevant quantitative traits, subclinical indicators of disease, and medical diagnoses are identified by using biomarkers, imaging, and other physiologic indicators. The AGES–Reykjavik sample is drawn from an established population-based cohort, the Reykjavik Study. This cohort of men and women born between 1907 and 1935 has been followed in Iceland since 1967 by the Icelandic Heart Association. The AGES–Reykjavik cohort, with cardiovascular risk factor assessments earlier in life and detailed late-life phenotypes of quantitative traits, will create a comprehensive study of aging nested in a relatively genetically homogeneous older population. This approach should facilitate identification of genetic factors that contribute to healthy aging as well as the chronic conditions common in old age.

aging; body composition; cardiovascular diseases; cognition; genetics, population; osteoporosis; phenotype

Abbreviations: AGES–Reykjavik, Age, Gene/Environment Susceptibility–Reykjavik Study


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Ann Rheum DisHome page
H Jonsson, G P Helgadottir, T Aspelund, G Eiriksdottir, S Sigurdsson, T Ingvarsson, T B Harris, L Launer, and V Gudnason
Hand osteoarthritis in older women is associated with carotid and coronary atherosclerosis: the AGES Reykjavik study
Ann Rheum Dis, November 1, 2009; 68(11): 1696 - 1700.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
J. S. Saczynski, S. Siggurdsson, P. V. Jonsson, G. Eiriksdottir, E. Olafsdottir, O. Kjartansson, T. B. Harris, M. A. van Buchem, V. Gudnason, and L. J. Launer
Glycemic Status and Brain Injury in Older Individuals: The Age Gene/Environment Susceptibility-Reykjavik Study
Diabetes Care, September 1, 2009; 32(9): 1608 - 1613.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
A. I. Scher, L. S. Gudmundsson, S. Sigurdsson, A. Ghambaryan, T. Aspelund, G. Eiriksdottir, M. A. van Buchem, V. Gudnason, and L. J. Launer
Migraine Headache in Middle Age and Late-Life Brain Infarcts
JAMA, June 24, 2009; 301(24): 2563 - 2570.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
J Franklin, T Ingvarsson, M Englund, and L S Lohmander
Sex differences in the association between body mass index and total hip or knee joint replacement resulting from osteoarthritis
Ann Rheum Dis, April 1, 2009; 68(4): 536 - 540.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J. S. Saczynski, S. Sigurdsson, M. K. Jonsdottir, G. Eiriksdottir, P. V. Jonsson, M. E. Garcia, O. Kjartansson, O. Lopez, M. A. van Buchem, V. Gudnason, et al.
Cerebral Infarcts and Cognitive Performance: Importance of Location and Number of Infarcts
Stroke, March 1, 2009; 40(3): 677 - 682.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
L. J. Launer
Diabetes: Vascular or Neurodegenerative: An Epidemiologic Perspective
Stroke, March 1, 2009; 40(3_suppl_1): S53 - S55.
[Full Text] [PDF]

Home page
 Circ Cardiovasc GenetHome page
B. M. Psaty, C. J. O'Donnell, V. Gudnason, K. L. Lunetta, A. R. Folsom, J. I. Rotter, A. G. Uitterlinden, T. B. Harris, J. C.M. Witteman, E. Boerwinkle, et al.
Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of Prospective Meta-Analyses of Genome-Wide Association Studies From 5 Cohorts
Circ Cardiovasc Genet, February 1, 2009; 2(1): 73 - 80.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
J. S. Saczynski, M. K. Jonsdottir, M. E. Garcia, P. V. Jonsson, R. Peila, G. Eiriksdottir, E. Olafsdottir, T. B. Harris, V. Gudnason, and L. J. Launer
Cognitive Impairment: An Increasingly Important Complication of Type 2 Diabetes: The Age, Gene/Environment Susceptibility-Reykjavik Study
Am. J. Epidemiol., November 15, 2008; 168(10): 1132 - 1139.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
J. S. Saczynski, M. K. Jonsdottir, S. Sigurdsson, G. Eiriksdottir, P. V. Jonsson, M. E. Garcia, O. Kjartansson, M. A. van Buchem, V. Gudnason, and L. J. Launer
White Matter Lesions and Cognitive Performance: The Role of Cognitively Complex Leisure Activity
J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2008; 63(8): 848 - 854.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
H. T. Bjornsson, M. I. Sigurdsson, M. D. Fallin, R. A. Irizarry, T. Aspelund, H. Cui, W. Yu, M. A. Rongione, T. J. Ekstrom, T. B. Harris, et al.
Intra-individual Change Over Time in DNA Methylation With Familial Clustering
JAMA, June 25, 2008; 299(24): 2877 - 2883.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C. Qiu, M. F. Cotch, S. Sigurdsson, M. Garcia, R. Klein, F. Jonasson, B. E.K. Klein, G. Eiriksdottir, T. B. Harris, M. A. van Buchem, et al.
Retinal and Cerebral Microvascular Signs and Diabetes: The Age, Gene/Environment Susceptibility-Reykjavik Study
Diabetes, June 1, 2008; 57(6): 1645 - 1650.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
G. F. Mitchell, V. Gudnason, L. J. Launer, T. Aspelund, and T. B. Harris
Hemodynamics of Increased Pulse Pressure in Older Women in the Community-Based Age, Gene/Environment Susceptibility-Reykjavik Study
Hypertension, April 1, 2008; 51(4): 1123 - 1128.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.