American Journal of Epidemiology Advance Access originally published online on February 23, 2007
American Journal of Epidemiology 2007 165(8):901-910; doi:10.1093/aje/kwm010
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ORIGINAL CONTRIBUTIONS |
Urine Nicotine Metabolites and Smoking Behavior in a Multiracial/Multiethnic National Sample of Young Adults
1 Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, New York, NY
2 Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY
3 New York State Psychiatric Institute, New York, NY
4 Department of Sociology, College of Arts and Sciences, University of North Carolina, Chapel Hill, NC
5 Department of Maternal and Child Health, School of Public Health, University of North Carolina, Chapel Hill, NC
6 Department of Medicine, School of Medicine, University of California San Francisco, San Francisco, CA
7 Department of Psychiatry, School of Medicine, University of California San Francisco, San Francisco, CA
8 Department of Biopharmaceutical Sciences, School of Pharmacy, University of California San Francisco, San Francisco, CA
Correspondence to Dr. Denise B. Kandel, Columbia University, 1051 Riverside Drive, Unit 20, New York, NY 10032 (e-mail: dbk2{at}columbia.edu).
Received for publication June 15, 2006. Accepted for publication October 2, 2006.
Nicotine metabolism has been hypothesized to affect patterns of smoking. The recent development of a noninvasive measure of nicotine metabolism, the nicotine metabolite ratio (trans-3'-hydroxycotinine/cotinine), makes it possible to examine the association between rate of nicotine metabolism and smoking behavior in the general population. This US study examined group differences in the ratio measured in urine and the association between the ratio and multiple measures of smoking behavior and nicotine dependence in a large, national representative sample of young adults. The sample included 900 daily smokers aged 18–26 years from wave III (2001–2002) of the National Longitudinal Survey of Adolescent Health. Nicotine dependence was measured by using the Fagerström Test for Nicotine Dependence. Females had higher nicotine metabolite ratios than males; Whites and Hispanics had higher nicotine metabolite ratios than African Americans or Asians. This finding is consistent with those from laboratory studies of older smokers based on intravenous infusion of nicotine. No significant association was found between the nicotine metabolite ratio and number of cigarettes smoked per day or nicotine dependence. The availability of a noninvasive measure makes possible systematic testing of causal hypotheses generated by laboratory studies in the general population.
adolescent; metabolism; nicotine; smoking; tobacco use disorder; urine
Abbreviations: Add Health, National Longitudinal Survey of Adolescent Health; COT, cotinine; CPD, number of cigarettes smoked per day; FTND, Fagerström Test for Nicotine Dependence; 3HC, trans-3'-hydroxycotinine
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