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American Journal of Epidemiology Advance Access originally published online on October 27, 2006
American Journal of Epidemiology 2007 165(1):36-43; doi:10.1093/aje/kwj367
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American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.

ORIGINAL CONTRIBUTIONS

Chromosomal Aberrations and Cancer Risk: Results of a Cohort Study from Central Europe

Paolo Boffetta1, Olga van der Hel1, Hannu Norppa2, Eleonora Fabianova3, Aleksandra Fucic4, Sarolta Gundy5, Juozas Lazutka6, Antonina Cebulska-Wasilewska7,8, Daniela Puskailerova3, Ariana Znaor9, Zsolt Kelecsenyi5, Juozas Kurtinaitis10, Jadwiga Rachtan11, Alessandra Forni12, Roel Vermeulen13 and Stefano Bonassi14

1 International Agency for Research on Cancer, Lyon, France
2 Finnish Institute of Occupational Health, Helsinki, Finland
3 Regional Public Health Authority, Banska Bystrica, Slovakia
4 Institute for Medical Research and Occupational Health, Zagreb, Croatia
5 National Institute of Oncology, Budapest, Hungary
6 Vilnius University, Vilnius, Lithuania
7 Epidemiology Department, Jagellonian University Medical College, Kraków, Poland
8 Institute of Nuclear Physics, Polish Academy of Sciences, Kraków, Poland
9 Croatian National Cancer Registry, Zagreb, Croatia
10 Lithuanian Cancer Register, Vilnius University Institute of Oncology, Vilnius, Lithuania
11 Cancer Epidemiology Department, Institute of Oncology, Kraków Branch, Kraków, Poland
12 Department of Occupational and Environmental Health, University of Milan, Milan, Italy
13 National Cancer Institute, Bethesda, MD
14 Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy

Correspondence to Dr. Paolo Boffetta, International Agency for Research on Cancer, 150 cours Albert Thomas, 69008 Lyon, France (e-mail: boffetta{at}iarc.fr).

A high level of chromosomal aberrations in peripheral blood lymphocytes may be an early marker of cancer risk, but data on risk of specific cancers and types of chromosomal aberrations (chromosome type and chromatid type) are limited. A total of 6,430 healthy individuals from nine laboratories in Croatia, Hungary, Lithuania, Poland, and Slovakia, included in chromosomal aberration surveys performed during 1978–2002, were followed up for cancer incidence or mortality for an average of 8.5 years; 200 cancer cases were observed. Compared with that for the low-tertile level of chromosomal aberrations, the relative risks of cancer for the medium and high tertiles were 1.78 (95% confidence interval: 1.19, 2.67) and 1.81 (95% confidence interval: 1.20, 2.73), respectively. The relative risk for chromosome-type aberrations above versus below the median was 1.50 (95% confidence interval: 1.12, 2.01), while that for chromatid-type aberrations was 0.97 (95% confidence interval: 0.72, 1.31). The analyses of risk of specific cancers were limited by small numbers, but the association was stronger for stomach cancer. This study confirms the previously reported association between level of chromosomal aberrations and cancer risk and provides novel information on the type of aberrations more strongly predictive of cancer risk and on the types of cancer more strongly predicted by chromosomal aberrations.

chromosome aberrations; cohort studies; cytogenetics; Europe; neoplasms; risk


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