American Journal of Epidemiology Advance Access originally published online on June 14, 2006
American Journal of Epidemiology 2006 164(2):176-183; doi:10.1093/aje/kwj165
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Original Contribution |
Smoking and Time to Clearance of Human Papillomavirus Infection in HIV-Seropositive and HIV-Seronegative Women
1 Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC
2 Division of Reproductive Health, Women's Health and Fertility Branch, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA
3 HIV Vaccine Trials Network, Seattle, WA
4 Office of the Chief Science Officer, Centers for Disease Control and Prevention, Atlanta, GA
5 Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD
6 Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY
7 Department of Obstetrics and Gynecology, Brown Medical School, Brown University, Providence, RI
8 Department of Infectious Disease and Quality Health Care, School of Medicine, Virginia Commonwealth University, Richmond, VA
9 Department of Medicine, Division of Infectious Diseases, School of Medicine, Wayne State University, Detroit, MI
10 Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD
Correspondence to Dr. Jill Koshiol, National Cancer Institute, 6120 Executive Blvd., MSC 7236, Bethesda, MD 20892-7236 (e-mail: koshiolj{at}mail.nih.gov).
Persistent human papillomavirus (HPV) infection seems central to cervical carcinogenesis. Smoking is associated with cervical cancer in HPV DNA-positive women, but its association with HPV persistence is unclear, particularly with respect to human immunodeficiency virus (HIV) serostatus. The authors evaluated smoking and HPV clearance by HIV serostatus among 801 women from the HIV Epidemiology Research Study (United States, 1993–2000). Type-specific HPV duration was defined as the interval between initial MY09/11 polymerase chain reaction positivity and the first of two consecutive HPV-negative study visits. Hazard ratios adjusted for study site and risk behaviors (sexual activity or injection drug use) were estimated using Cox regression. This analysis included 522 HIV-seropositive and 279 HIV-seronegative women (median follow-up, 4.4 years). Ever smoking was associated with reduced clearance of high-risk HPV in HIV-seronegative women (hazard ratio (HR) = 0.51, 95% confidence interval (CI): 0.30, 0.88) but not in HIV-seropositive women (HR = 0.96, 95% CI: 0.65, 1.42); similar results were found for current smoking. Current smoking was not associated with clearance of any type-specific HPV in HIV-seropositive (HR = 0.99, 95% CI: 0.82, 1.20) or HIV-seronegative (HR = 0.93, 95% CI: 0.68, 1.26) women. HPV clearance did not appear to vary by amount or duration of smoking. Smoking did not modify overall clearance but was associated with lower high-risk HPV clearance in HIV-seronegative women.
HIV; papillomavirus, human; smoking; women
Abbreviations: CI, confidence interval; HERS, HIV Epidemiology Research Study; HIV, human immunodeficiency virus; HPV, human papillomavirus; HR, hazard ratio
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Vaccarella, R. Herrero, P. J F Snijders, M. Dai, J. O Thomas, N. T. Hieu, C. Ferreccio, E. Matos, H. Posso, S. de Sanjose, et al. Smoking and human papillomavirus infection: pooled analysis of the International Agency for Research on Cancer HPV Prevalence Surveys Int. J. Epidemiol., June 1, 2008; 37(3): 536 - 546. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Gunnell, T. N. Tran, A. Torrang, P. W. Dickman, P. Sparen, J. Palmgren, and N. Ylitalo Synergy between Cigarette Smoking and Human Papillomavirus Type 16 in Cervical Cancer In situ Development Cancer Epidemiol. Biomarkers Prev., November 1, 2006; 15(11): 2141 - 2147. [Abstract] [Full Text] [PDF]
|
|