American Journal of Epidemiology Advance Access originally published online on May 17, 2006
American Journal of Epidemiology 2006 164(2):136-142; doi:10.1093/aje/kwj184
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Original Contribution |
The Relation between Components of Adult Height and Intimal-Medial Thickness in Middle Age
The Atherosclerosis Risk in Communities Study
1 Department of Social Medicine, University of Bristol, Bristol, United Kingdom
2 Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill, NC
3 Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
Correspondence to Dr. Kate Tilling, Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, United Kingdom (e-mail: kate.tilling{at}bristol.ac.uk).
The authors aimed to investigate the relation between components of adult height (leg and trunk length) and atherosclerosis in middle age, using data from 12,254 participants (aged 44–65 years) in the Atherosclerosis Risk in Communities (ARIC) Study. Intimal-medial thickness (IMT) as measured by B-mode ultrasound was the outcome, and exposures were trunk and leg lengths as estimated (using sitting height and the difference between sitting and standing height) at the first study examination in 1987–1989. The mean IMT was 0.73 (standard deviation, 0.17) mm. Greater leg length was associated with lower IMT, with the largest difference being for Black men (a 0.045 (95% confidence interval: 0.023, 0.068)-mm lower IMT per 10-cm higher leg length). Greater trunk length was associated with higher IMT, with the largest difference being for White men (a 0.024 (95% confidence interval: 0.005, 0.044)-mm higher IMT per 10-cm higher trunk length). Although the effect sizes were small, leg length was inversely associated with atherosclerosis, consistent with the results of other studies with cardiovascular disease outcomes.
body height; coronary artery diseases; leg; socioeconomic factors
Abbreviations: ARIC, Atherosclerosis Risk in Communities; CI, confidence interval; IMT, intimal-medial thickness
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