American Journal of Epidemiology Advance Access originally published online on March 1, 2006
American Journal of Epidemiology 2006 163(9):818-828; doi:10.1093/aje/kwj104
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Original Contribution |
Maternal and Infant Birth Characteristics and Hepatoblastoma
1 New York State Cancer Registry, New York State Department of Health, Albany, NY
2 School of Public Health, State University of New York at Albany, Albany, NY
3 Division of Chronic Disease Prevention and Adult Health, New York State Department of Health, Albany, NY
4 School of Public Health and Health Sciences, University of Massachusetts at Amherst, Amherst, MA
Correspondence to Colleen C. McLaughlin, New York State Cancer Registry, New York State Department of Health, Corning Tower Room 536, Empire State Plaza, Albany, NY 12237-0679 (e-mail: ccm01{at}health.state.ny.us).
Hepatoblastoma is a rare embryonal tumor with unknown etiology. The authors conducted a case-cohort study using public health surveillance data sets to examine perinatal risk factors for hepatoblastoma. Hepatoblastoma cases (n = 58) diagnosed between 1985 and 2001 were identified from the New York State Cancer Registry and were matched to electronic birth records for 1985–2001 from New York State, excluding New York City. Controls (n = 6,056) were selected from the birth cohorts for the same years. Having a birth weight less than 1,000 g was associated with a strongly increased risk of hepatoblastoma (relative risk (RR) = 56.9, 95% confidence interval (CI): 24.0, 130.7). After adjustment for birth weight, a moderately increased risk of hepatoblastoma was found for younger maternal age (<20 years vs. 20–29 years: RR = 2.5, 95% CI: 1.0, 5.5), presumptive use of infertility treatment (RR = 9.2, 95% CI: 2.1, 31.5), maternal smoking (RR = 2.1, 95% CI: 1.0, 4.2), and higher maternal prepregnancy body mass index (body mass index of 25–29 vs. 20–24: RR = 2.9, 95% CI: 1.2, 7.6).
hepatoblastoma; infant, very low birth weight; maternal age; maternal welfare; reproductive techniques, assisted
Abbreviations: APC, adenomatous polyposis coli; CI, confidence interval; CTNNB1, cadherin-associated protein ß1; RR, relative risk
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