Skip Navigation


American Journal of Epidemiology Advance Access originally published online on February 8, 2006
American Journal of Epidemiology 2006 163(6):528-533; doi:10.1093/aje/kwj070
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
163/6/528    most recent
kwj070v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Cameron, J. C.
Right arrow Articles by Boyd, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cameron, J. C.
Right arrow Articles by Boyd, J. H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.

Original Contribution

Oral Polio Vaccine and Intussusception: A Data Linkage Study using Records for Vaccination and Hospitalization

J. Claire Cameron1, David Walsh2, Alan R. Finlayson3 and James H. Boyd3

1 Health Protection Scotland, Glasgow, United Kingdom
2 Health Scotland, Glasgow, United Kingdom
3 ISD Scotland, Edinburgh, United Kingdom

Correspondence to Dr. Claire Cameron, Health Protection Scotland, Clifton House, Clifton Place, Glasgow G3 7LN, Scotland, United Kingdom (e-mail: claire.cameron{at}hps.scot.nhs.uk).

The authors investigated the possibility of an association between oral polio vaccine (OPV) and intussusception by linking Scottish vaccination and hospitalization data sets and performing self-controlled case series analysis. The issue was important because rotavirus vaccine, another live oral virus vaccine, was withdrawn from the market in 1999 after studies showed a strong association with intussusception. OPV was recommended for all infants in the United Kingdom at ages 2, 3, and 4 months until 2004, when new combination vaccines containing inactivated poliovirus were introduced. Analysis was carried out for 466 intussusception cases occurring in 1987–1999 for which linked records on OPV vaccination were available. Six possible risk periods for intussusception, ranging from 3 days after vaccination to 41 days after vaccination, were examined, with separate analysis for each of the three OPV doses and also for data on all three doses combined. Of the 24 possible risk periods examined, the relative incidence of intussusception after vaccination was unchanged for 18, significantly decreased for five, and significantly increased for only one. The authors conclude that overall, there is no evidence for an association between OPV and intussusception, even when each dose is considered separately.

intussusception; medical record linkage; poliovirus vaccines

Abbreviations: CI, confidence interval; OPV, oral polio vaccine; RI, relative incidence; SCCS, self-controlled case series


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.