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American Journal of Epidemiology Advance Access originally published online on March 29, 2006
American Journal of Epidemiology 2006 163(10):877-887; doi:10.1093/aje/kwj119
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American Journal of Epidemiology Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved; printed in U.S.A.

Original Contribution

Psychosocial Work Environment and Incidence of Severe Depressive Symptoms: Prospective Findings from a 5-Year Follow-up of the Danish Work Environment Cohort Study

Reiner Rugulies, Ute Bültmann, Birgit Aust and Hermann Burr

From the National Institute of Occupational Health, Copenhagen, Denmark

Correspondence to Dr. Reiner Rugulies, National Institute of Occupational Health, Lersø Parkallé 105, DK-2100 Copenhagen, Denmark (e-mail: rer{at}ami.dk).

The authors analyzed the impact of psychosocial work characteristics on the incidence of severe depressive symptoms among 4,133 (49% women) employees from a representative sample of the Danish workforce between 1995 and 2000. Psychosocial work characteristics at baseline included quantitative demands, influence at work, possibilities for development, social support from supervisors and coworkers, and job insecurity. Severe depressive symptoms were measured with the five-item Mental Health Inventory of the 36-item Short-Form Health Survey, with a cutoff point of 52. Women with low influence at work (relative risk (RR) = 2.17, 95% confidence interval (CI): 1.23, 3.82) and low supervisor support (RR = 2.03, 95% CI: 1.20, 3.43) were at increased risk for severe depressive symptoms after exclusion of cases at baseline and adjustment for sociodemographic factors, baseline depression score, and health behaviors. Further adjustments for socioeconomic position did not change the result substantially. Additional analyses showed that a one-standard deviation increase on the influence scale resulted in a 27% decreased risk of severe depressive symptoms. Among men, job insecurity predicted severe depressive symptoms (RR = 2.04, 95% CI: 1.02, 4.07). The findings indicate that the work environment influences the risk of developing severe depressive symptoms and that different factors play a role for men and women.

anxiety; depression; longitudinal studies; mental health; social support; stress, psychological; workplace


Abbreviations: CI, confidence interval; DWECS, Danish Work Environment Cohort Study; MHI-5, five-item Mental Health Inventory of the 36-item Short-Form Health Survey; RR, relative risk


Editor's note: An invited commentary on this article appears on page 888, and the author's response appears on page 891.


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