ORIGINAL CONTRIBUTIONS |
Use of Antibiotics and Risk of Breast Cancer
From the Spanish Center for Pharmacoepidemiologic Research, Madrid, Spain
Correspondence to Dr. Antonio González-Pérez, Centro Español de Investigación Farmacoepidemiológica (CEIFE), Almirante 28, 28004 Madrid, Spain (e-mail: agonzalez{at}ceife.es).
A recent nested case-control study found that increasing use of antibiotics was associated with a significantly elevated risk of breast cancer. The authors attempted to replicate this finding with a similar study design using the General Practice Research Database in the United Kingdom. Women aged 30–79 years who were registered in the database between January 1995 and December 2001 comprised the study cohort. A total of 3,708 women with incident cases of breast cancer and 20,000 frequency-matched controls were entered into a nested case-control analysis. Use of antibiotics was not associated with an increased risk of breast cancer. For categories of increasing cumulative days of use (1–50, 51–100, 101–500, and 
501 days), the corresponding odds ratios were 1.0 (95% confidence interval (CI): 0.9, 1.1), 1.0 (95% CI: 0.8, 1.1), 0.9 (95% CI: 0.7, 1.0), and 1.2 (95% CI: 0.9, 1.6) (p = 0.31 for trend). On the basis of these results, antibiotic use does not appear to be a major determinant of breast cancer risk.
anti-bacterial agents; breast neoplasms
Abbreviations: CI, confidence interval
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