ORIGINAL CONTRIBUTIONS |
Risk of Urinary Tract Infection and Asymptomatic Bacteriuria among Diabetic and Nondiabetic Postmenopausal Women
1 Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, WA
2 Department of Medicine, School of Medicine, University of Washington, Seattle, WA
3 Northwest Health Services Research and Development Program, VA Puget Sound Health Care System, Seattle, WA
4 Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA
5 Center for Health Studies, Group Health Cooperative of Puget Sound, Seattle, WA
Correspondence to Dr. Edward J. Boyko, VA Puget Sound Health Care System (S-152E), 1660 South Columbian Way, Seattle, WA 98108 (e-mail: eboyko{at}u.washington.edu).
No prospective data exist on the risk of microbiologically confirmed urinary tract infection (UTI) and asymptomatic bacteriuria (AB) in relation to diabetes mellitus and its characteristics. The authors prospectively (1998–2002) followed 218 diabetic and 799 nondiabetic Washington State women aged 55–75 years for UTI and AB. The baseline examination and two annual follow-up examinations included urine culture, measurement of hemoglobin A1c and postvoid residual bladder volume, and a survey of diabetes and other characteristics. Surveillance for UTI included self-reports confirmed by microbiologic culture and medical record review. UTI incidence per 100 person-years was 12.2 for diabetic women and 6.7 for nondiabetic women (relative risk (RR) = 1.8, 95% confidence interval (CI): 1.2, 2.7). AB incidence per 100 person-years was 6.7 for diabetic women and 3.0 for nondiabetic women (RR = 2.3, 95% CI: 1.3, 3.9). In Cox models adjusted for multiple covariates, the increased UTI risk occurred mainly in women taking insulin (RR = 3.7, 95% CI: 1.8, 7.3) and women with a longer diabetes duration (
10 years; RR = 2.6, 95% CI: 1.3, 5.1) compared with nondiabetic women. No clear linear trend between hemoglobin A1c and UTI or AB risk was seen. Postmenopausal women with diabetes have higher risks of UTI and AB in relation to diabetes duration and severity but not to recent glucose control.
diabetes mellitus; postmenopause; prospective studies; risk factors; urinary tract infection; women
Abbreviations: GHC Group Health Cooperative of Puget Sound; UTI urinary tract infection
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. A. Rosen, C.-S. Hung, K. A. Kline, and S. J. Hultgren Streptozocin-Induced Diabetic Mouse Model of Urinary Tract Infection Infect. Immun., September 1, 2008; 76(9): 4290 - 4298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Walrand, C. Guillet, Y. Boirie, and M.-P. Vasson Insulin Differentially Regulates Monocyte and Polymorphonuclear Neutrophil Functions in Healthy Young and Elderly Humans J. Clin. Endocrinol. Metab., July 1, 2006; 91(7): 2738 - 2748. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Jackson, D. Scholes, E. J. Boyko, L. Abraham, and S. D. Fihn Urinary Incontinence and Diabetes in Postmenopausal Women Diabetes Care, July 1, 2005; 28(7): 1730 - 1738. [Abstract] [Full Text] [PDF]
|
|