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American Journal of Epidemiology 2005 161(12):1133-1143; doi:10.1093/aje/kwi151
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American Journal of Epidemiology Copyright © 2005 by the Johns Hopkins Bloomberg School of Public Health All rights reserved

ORIGINAL CONTRIBUTIONS

The Effect of Weight History on Glucose and Lipids

The Atherosclerosis Risk in Communities Study

Kimberly P. Truesdale1, June Stevens1,2 and Jianwen Cai3

1 Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC
2 Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC
3 Department of Biostatistics, School of Public Health, University of North Carolina, Chapel Hill, NC

Correspondence to Dr. Kimberly P. Truesdale, Department of Epidemiology, CB 7435, University of North Carolina, Chapel Hill, NC 27599 (e-mail: Kim_Truesdale{at}unc.edu).

Few studies have examined the impact of weight history. Extant data from the Atherosclerosis Risk in Communities Study were used to compare risk factors for normal-weight (body mass index: 18.5–24.9 kg/m2) adults with a history of weight loss (n = 775) with those for persons with a history of weight maintenance (n = 5,164). In this 1987–1998 US study, the authors also compared risk factors for preobese (body mass index: 25.0–29.9 kg/m2) adults with a history of weight gain (n = 1,296) versus weight maintenance (n = 6,721). They used mixed-models regression to adjust for ethnicity, gender, age, education, field center, smoking, alcohol consumption, follow-up time, and follow-up body mass index. Compared with adults with a history of weight maintenance, adults with a 3-year history of weight loss had more favorable total and low density lipoprotein cholesterol levels and similar glucose, high density lipoprotein cholesterol, and triglyceride levels. In contrast, preobese adults with a 3-year history of weight gain had equivalent glucose and lipid levels at follow-up compared with adults with a history of weight maintenance. These findings suggest that, in addition to current weight, weight history may impact glucose and lipid levels.

glucose; lipoproteins, HDL cholesterol; lipoproteins, LDL cholesterol; obesity; triglycerides; weight gain; weight loss

Abbreviations: AHFSCC, American Hospital Formulary Service Classification Compilation; BMI, body mass index; HDL, high density lipoprotein; LDL, low density lipoprotein; MTC, Medi-Span Therapeutic Classification


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