ORIGINAL CONTRIBUTIONS |
Prospective Study of Dietary Fat and Risk of Cataract Extraction among US Women
1 Nutritional Epidemiology Program, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA
2 Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
3 Laboratory for Nutrition and Vision Research, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA
4 Department of Epidemiology, Harvard School of Public Health, Boston, MA
5 Department of Nutrition, Harvard School of Public Health, Boston, MA
Correspondence to Dr. Paul F. Jacques, Nutritional Epidemiology Program, US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111 (e-mail: paul.jacques{at}tufts.edu).
The authors examined prospectively the association between dietary fat intake and cataract extraction in adult women from the Nurses' Health Study. A total of 71,083 women were followed prospectively for up to 16 years between 1984 and 2000. Dietary fat was assessed by repeated food frequency questionnaires. Incident cases of cataract extraction were determined by a biennial questionnaire. The multivariate-adjusted relative risk for the highest compared with the lowest quintile of total fat intake was 1.10 (95% confidence interval (CI): 0.99, 1.22; ptrend = 0.01). Women in the highest quintile of long-chain omega-3 fatty acid had a 12% lower risk of cataract extraction compared with those in the lowest quintile (relative risk = 0.88, 95% CI: 0.79, 0.98; ptrend = 0.02). Total fish intake was inversely associated with cataract (for intake of 
3/week vs. <1/month: relative risk = 0.89, 95% CI: 0.81, 0.98; ptrend = 0.01). The authors' findings suggest that higher intake of long-chain omega-3 fatty acid (eicosapentaenoic acid and docosahexaenoic acid) and consumption of fish may modestly reduce the risk of cataract.
cataract extraction; dietary fats; fatty acids, omega-3; trans fatty acids
Abbreviations: CI, confidence interval
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. M. Moeller, R. Voland, L. Tinker, B. A. Blodi, M. L. Klein, K. M. Gehrs, E. J. Johnson, D. M. Snodderly, R. B. Wallace, R. J. Chappell, et al. Associations Between Age-Related Nuclear Cataract and Lutein and Zeaxanthin in the Diet and Serum in the Carotenoids in the Age-Related Eye Disease Study (CAREDS), an Ancillary Study of the Women's Health Initiative Arch Ophthalmol, March 1, 2008; 126(3): 354 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lu, A. Taylor, L. T. Chylack Jr, G. Rogers, S. E. Hankinson, W. C. Willett, and P. F. Jacques Dietary Linolenic Acid Intake Is Positively Associated with Five-Year Change in Eye Lens Nuclear Density J. Am. Coll. Nutr., April 1, 2007; 26(2): 133 - 140. [Abstract] [Full Text] [PDF]
|
|