HUMAN GENOME EPIDEMIOLOGY (HuGE) REVIEW |
Cytochrome P-450 1A1 Gene Polymorphisms and Risk of Breast Cancer: A HuGE Review
From the Epidemiology Group, Department of Public Health, University of Aberdeen, Aberdeen, Scotland
Correspondence to Dr. Lindsey F. Masson, Epidemiology Group, Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, Scotland (e-mail: lindsey.masson{at}abdn.ac.uk).
Cytochrome P-450 (CYP) 1A1 plays a key role in phase I metabolism of polycyclic aromatic hydrocarbons and in estrogen metabolism. It is expressed predominantly in extrahepatic tissues, including the breast. Four CYP1A1 gene polymorphisms (3801T
C, Ile462Val, 3205TC, and Thr461Asp) have been studied in relation to breast cancer. The 3801C variant is more common than the Val variant. Both variants occur more frequently in Asians than in White populations. The 3205TC polymorphism has been observed in African Americans only. Little data are available on the geographic/ethnic distribution of the Thr461Asp polymorphism. The functional significance of the polymorphisms is unclear. In 17 studies, no consistent association between breast cancer and CYP1A1 genotype was found. Meta-analysis found no significant risk for the genotypes 1) 3801C/C (relative risk (RR) = 0.97, 95% confidence interval (CI): 0.52, 1.80) or 3801T/C (RR = 0.91, 95% CI: 0.70, 1.19) versus 3801T/T, 2) Val/Val (RR = 1.04, 95% CI: 0.63, 1.74) or Ile/Val (RR = 0.92, 95% CI: 0.76, 1.10) versus Ile/Ile, or 3) Asp/Asp (RR = 0.95, 95% CI: 0.20, 4.49) or Thr/Asp (RR = 1.12, 95% CI: 0.87, 1.43) versus Thr/Thr. Future studies should explore possible interactions between CYP1A1 and sources of polycyclic aromatic hydrocarbons, markers of estrogen exposure, other lifestyle factors influencing hormonal levels, and other genes involved in polycyclic aromatic hydrocarbon metabolism or hormonal biosynthesis.
breast neoplasms; cytochrome P-450 CYP1A1; epidemiology; polymorphism, genetic
Abbreviations: CI, confidence interval; COMT, catechol-O-methyltransferase; CYP, cytochrome P-450; GST, glutathione S-transferase; PAH, polycyclic aromatic hydrocarbon; PCB, polychlorinated biphenyl; RR, relative risk
Editor's note: This paper is also available on the website of the Human Genome Epidemiology Network (http://www.cdc.gov/genomics/hugenet/).
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  K. D. Crew, M. D. Gammon, M. B. Terry, F. F. Zhang, L. B. Zablotska, M. Agrawal, J. Shen, C.-M. Long, S. M. Eng, S. K. Sagiv, et al. Polymorphisms in Nucleotide Excision Repair Genes, Polycyclic Aromatic Hydrocarbon-DNA Adducts, and Breast Cancer Risk Cancer Epidemiol. Biomarkers Prev., October 1, 2007; 16(10): 2033 - 2041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. A. Ioannidis Common genetic variants for breast cancer: 32 largely refuted candidates and larger prospects. J Natl Cancer Inst, October 4, 2006; 98(19): 1350 - 1353. [Full Text] [PDF]
|
|
|
|
 |
|
 S.H. Juo, T.N. Wang, J.N. Lee, M.T. Wu, C.Y. Long, and E.M. Tsai CYP17, CYP1A1 and COMT polymorphisms and the risk of adenomyosis and endometriosis in Taiwanese women Hum. Reprod., June 1, 2006; 21(6): 1498 - 1502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Terry and M. Goodman Is the Association between Cigarette Smoking and Breast Cancer Modified by Genotype? A Review of Epidemiologic Studies and Meta-analysis. Cancer Epidemiol. Biomarkers Prev., April 1, 2006; 15(4): 602 - 611. [Abstract] [Full Text] [PDF]
|
|