Copyright © 2004 by the Johns Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Associations of Seafood and Elongated n-3 Fatty Acid Intake with Fetal Growth and Length of Gestation: Results from a US Pregnancy Cohort
1 Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA.
2 Maternal Nutrition Group, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen, Denmark.
3 Department of Maternal and Child Health, Harvard School of Public Health, Boston, MA.
4 Department of Nutrition, Harvard School of Public Health, Boston, MA.
Previous studies, mainly among populations with high consumption of seafood, have suggested that increased marine n-3 polyunsaturated fatty acid (PUFA) intake during pregnancy promotes longer gestation and higher birth weight. Few studies have isolated the contribution of fetal growth to birth weight. Using data from 2,109 pregnant women in Massachusetts enrolled in Project Viva from 1999 to 2002, the authors examined associations of marine n-3 PUFA and seafood intake with birth weight and birth-weight-for-gestational-age z value (fetal growth) using linear regression; length of gestation using median regression; and low birth weight, preterm delivery, and being small for gestational age using logistic regression. After adjustment for maternal and child factors, birth weight was 94 (95% confidence interval: 23, 166) g lower and fetal growth z value 0.19 (95% confidence interval: 0.08, 0.31) units lower in the highest compared with the lowest quartile of first-trimester n-3 PUFA intake. Results for the second and third trimesters were similar, and findings for seafood paralleled those for n-3 PUFA. Elongated n-3 PUFA intake and seafood intake were not associated with length of gestation or risk of preterm birth. Results from this US cohort support the conclusion that seafood intake during pregnancy is associated with reduced fetal growth.
birth weight; fatty acids, omega-3; fetal growth retardation; gestational age; prenatal nutrition; seafood
Abbreviations: Abbreviations: CI: confidence interval; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; PUFA, polyunsaturated fatty acids; SFFQ, semiquantitative food frequency questionnaire.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. Oken, J. S. Radesky, R. O. Wright, D. C. Bellinger, C. J. Amarasiriwardena, K. P. Kleinman, H. Hu, and M. W. Gillman Maternal Fish Intake during Pregnancy, Blood Mercury Levels, and Child Cognition at Age 3 Years in a US Cohort Am. J. Epidemiol., May 15, 2008; 167(10): 1171 - 1181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. van Eijsden, G. Hornstra, M. F van der Wal, T. G. Vrijkotte, and G. J Bonsel Maternal n-3, n-6, and trans fatty acid profile early in pregnancy and term birth weight: a prospective cohort study Am. J. Clinical Nutrition, April 1, 2008; 87(4): 887 - 895. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D Fountain, J. Mao, J. J Whyte, K. E Mueller, M. R Ellersieck, M. J Will, R. M. Roberts, R. MacDonald, and C. S Rosenfeld Effects of Diets Enriched in Omega-3 and Omega-6 Polyunsaturated Fatty Acids on Offspring Sex-Ratio and Maternal Behavior in Mice Biol Reprod, February 1, 2008; 78(2): 211 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. P. Gunderson, S. L. Rifas-Shiman, E. Oken, J. W. Rich-Edwards, K. P. Kleinman, E. M. Taveras, and M. W. Gillman Association of Fewer Hours of Sleep at 6 Months Postpartum with Substantial Weight Retention at 1 Year Postpartum Am. J. Epidemiol., January 15, 2008; 167(2): 178 - 187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Th. I. Halldorsson, H. Meltzer, I Thorsdottir, V Knudsen, and S. Olsen Is High Consumption of Fatty Fish during Pregnancy a Risk Factor for Fetal Growth Retardation? A Study of 44,824 Danish Pregnant Women Am. J. Epidemiol., September 15, 2007; 166(6): 687 - 696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Wathes, D. R. E. Abayasekara, and R. J. Aitken Polyunsaturated Fatty Acids in Male and Female Reproduction Biol Reprod, August 1, 2007; 77(2): 190 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Oken, Y. Ning, S. L. Rifas-Shiman, J. S. Radesky, J. W. Rich-Edwards, and M. W. Gillman Associations of physical activity and inactivity before and during pregnancy with glucose tolerance. Obstet. Gynecol., November 1, 2006; 108(5): 1200 - 1207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A Litonjua, S. L Rifas-Shiman, N. P Ly, K. G Tantisira, J. W Rich-Edwards, C. A Camargo Jr, S. T Weiss, M. W Gillman, and D. R Gold Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age. Am. J. Clinical Nutrition, October 1, 2006; 84(4): 903 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Szajewska, A. Horvath, and B. Koletzko Effect of n-3 long-chain polyunsaturated fatty acid supplementation of women with low-risk pregnancies on pregnancy outcomes and growth measures at birth: a meta-analysis of randomized controlled trials Am. J. Clinical Nutrition, June 1, 2006; 83(6): 1337 - 1344. [Abstract] [Full Text] [PDF]
|
|