Skip Navigation

American Journal of Epidemiology 2004 160(8):741-749; doi:10.1093/aje/kwh281
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (22)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Nicklas, B. J.
Right arrow Articles by Harris, T. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nicklas, B. J.
Right arrow Articles by Harris, T. B.
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2004 by the Johns Hopkins Bloomberg School of Public Health

ORIGINAL CONTRIBUTIONS

Association of Visceral Adipose Tissue with Incident Myocardial Infarction in Older Men and Women

The Health, Aging and Body Composition Study

Barbara J. Nicklas1 , Brenda W. J. H. Penninx1, Matteo Cesari1, Stephen B. Kritchevsky2, Anne B. Newman3, Alka M. Kanaya4, Marco Pahor1, Ding Jingzhong5 and Tamara B. Harris5

1 Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest University School of Medicine, Winston-Salem, NC.
2 Department of Preventive Medicine, University of Tennessee, Memphis, TN.
3 Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
4 Division of General Internal Medicine, University of California, San Francisco, CA.
5 Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD.

Assessment of body fat distribution, particularly visceral adipose tissue, may be important for accurate risk evaluation for cardiovascular disease in the elderly. This 1997–1998 US study examined the association of incident myocardial infarction (MI) with total adiposity (body mass index and fat mass) and body fat distribution (waist-to-thigh ratio, waist circumference, visceral and subcutaneous adipose tissue) in well-functioning men (n = 1,116) and women (n = 1,387) aged 70–79 years enrolled in the Health, Aging and Body Composition Study. There were 116 MI events (71 in men, 45 in women) during an average follow-up time of 4.6 (standard deviation, 0.9) years. No association was found between incident MI and the adiposity or fat distribution variables for men. For women, visceral adipose tissue was an independent predictor of MI (hazard ratio = 1.67, 95% confidence interval: 1.28, 2.17 per standard-deviation increase; p < 0.001). No association was found between body mass index or total fat mass and MI events in women. The association of visceral adipose tissue with MI in women was independent of high density lipoprotein cholesterol, interleukin-6 concentration, hypertension, and diabetes (hazard ratio = 1.79, 95% confidence interval: 1.24, 2.58 per standard-deviation increase; p < 0.01). The amount of adipose tissue stored in the intraabdominal cavity is an important, independent risk factor for MI in well-functioning, elderly women.

aged; body composition; myocardial infarction; obesity

Abbreviations: Abbreviations: BMI, body mass index; CHD, coronary heart disease; Health ABC, Health, Aging and Body Composition; MI, myocardial infarction.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
Am. J. Clin. Nutr.Home page
R. Scherzer, W. Shen, P. Bacchetti, D. Kotler, C. E Lewis, M. G Shlipak, S. B Heymsfield, and Carl Grunfeld for the Study of Fat Redistribution
Simple anthropometric measures correlate with metabolic risk indicators as strongly as magnetic resonance imaging-measured adipose tissue depots in both HIV-infected and control subjects
Am. J. Clinical Nutrition, June 1, 2008; 87(6): 1809 - 1817.
[Abstract] [Full Text] [PDF]


Home page
StrokeHome page
S. A. Lear, K. H. Humphries, S. Kohli, J. J. Frohlich, C. L. Birmingham, and G. B. J. Mancini
Visceral Adipose Tissue, a Potential Risk Factor for Carotid Atherosclerosis: Results of the Multicultural Community Health Assessment Trial (M-CHAT)
Stroke, September 1, 2007; 38(9): 2422 - 2429.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
C.-D. Lee, D. R Jacobs Jr, P. J Schreiner, C. Iribarren, and A. Hankinson
Abdominal obesity and coronary artery calcification in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study
Am. J. Clinical Nutrition, July 1, 2007; 86(1): 48 - 54.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JHome page
L. de Koning, A. T. Merchant, J. Pogue, and S. S. Anand
Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies
Eur. Heart J., April 2, 2007; (2007) ehm026v1.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
M. Cesari, S. B Kritchevsky, R. N Baumgartner, H. H Atkinson, B. W. Penninx, L. Lenchik, S. L Palla, W. T Ambrosius, R. P Tracy, and M. Pahor
Sarcopenia, obesity, and inflammation--results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors study
Am. J. Clinical Nutrition, August 1, 2005; 82(2): 428 - 434.
[Abstract] [Full Text] [PDF]



Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.