Copyright © 2004 by the Johns Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Relation of Contraceptive and Reproductive History to Ovarian Cancer Risk in Carriers and Noncarriers of BRCA1 Gene Mutations
1 Departments of Health Research and Policy and Medicine, Stanford University School of Medicine, Stanford, CA.
2 Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY.
3 Northern California Cancer Center, Union City, CA.
In the general population, ovarian cancer risk is inversely associated with oral contraceptive use, tubal ligation, and childbearing. Among carriers of BRCA1 gene mutations, the data are conflicting. The authors identified women diagnosed with incident invasive epithelial ovarian cancer in the San Francisco Bay Area of California from March 1997 through July 2001. They compared the contraceptive and reproductive histories of 36 carrier cases and 381 noncarrier cases with those of 568 controls identified by random digit dialing who were frequency matched to cases on age and race/ethnicity. In both carriers and noncarriers, reduced risk was associated with ever use of oral contraceptives (odds ratio = 0.54 (95% confidence interval (CI): 0.26, 1.13) for carriers and 0.55 (95% CI: 0.41, 0.73) for noncarriers), duration of oral contraceptive use (risk reduction per year = 13% (p = 0.01) for carriers and 6% (p < 0.001) for noncarriers), history of tubal ligation (odds ratio = 0.68 (95% CI: 0.25, 1.90) for carriers and 0.65 (95% CI: 0.45, 0.95) for noncarriers), and increasing parity (risk reduction per childbirth = 16% (p = 0.26) for carriers and 24% (p < 0.001) for noncarriers). These data suggest that BRCA1 mutation carriers and noncarriers have similar risk reductions associated with oral contraceptive use, tubal ligation, and parity.
contraceptives, oral; genes, BRCA1; mutation; ovarian neoplasms; parity; sterilization, tubal
Abbreviations: Abbreviations: CI, confidence interval; PTT, protein truncation test; SSCP, single-strand conformation polymorphism.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. M. Schildkraut, E. L. Goode, M. A. Clyde, E. S. Iversen, P. G. Moorman, A. Berchuck, J. R. Marks, J. Lissowska, L. Brinton, B. Peplonska, et al. Single Nucleotide Polymorphisms in the TP53 Region and Susceptibility to Invasive Epithelial Ovarian Cancer Cancer Res., March 15, 2009; 69(6): 2349 - 2357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Antoniou, M. Rookus, N. Andrieu, R. Brohet, J. Chang-Claude, S. Peock, M. Cook, D. G. Evans, R. Eeles, EMBRACE, et al. Reproductive and Hormonal Factors, and Ovarian Cancer Risk for BRCA1 and BRCA2 Mutation Carriers: Results from the International BRCA1/2 Carrier Cohort Study Cancer Epidemiol. Biomarkers Prev., February 1, 2009; 18(2): 601 - 610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Palmieri, M. A. Wilson, E. S. Iversen, M. A. Clyde, B. Calingaert, P. G. Moorman, C. Poole, A. R. Anderson, S. Anderson, H. Anton-Culver, et al. Polymorphism in the IL18 Gene and Epithelial Ovarian Cancer in Non-Hispanic White Women Cancer Epidemiol. Biomarkers Prev., December 1, 2008; 17(12): 3567 - 3572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lee, H. Ma, R. McKean-Cowdin, D. Van Den Berg, L. Bernstein, B. E. Henderson, and G. Ursin Effect of Reproductive Factors and Oral Contraceptives on Breast Cancer Risk in BRCA1/2 Mutation Carriers and Noncarriers: Results from a Population-Based Study Cancer Epidemiol. Biomarkers Prev., November 1, 2008; 17(11): 3170 - 3178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Allain Genetic Counseling and Testing for Common Hereditary Breast Cancer Syndromes: A Paper from the 2007 William Beaumont Hospital Symposium on Molecular Pathology J. Mol. Diagn., September 1, 2008; 10(5): 383 - 395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Greene, M. Piedmonte, D. Alberts, M. Gail, M. Hensley, Z. Miner, P. L. Mai, J. Loud, G. Rodriguez, J. Basil, et al. A Prospective Study of Risk-Reducing Salpingo-oophorectomy and Longitudinal CA-125 Screening among Women at Increased Genetic Risk of Ovarian Cancer: Design and Baseline Characteristics: A Gynecologic Oncology Group Study Cancer Epidemiol. Biomarkers Prev., March 1, 2008; 17(3): 594 - 604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Brohet, D. E. Goldgar, D. F. Easton, A. C. Antoniou, N. Andrieu, J. Chang-Claude, S. Peock, R. A. Eeles, M. Cook, C. Chu, et al. Oral Contraceptives and Breast Cancer Risk in the International BRCA1/2 Carrier Cohort Study: A Report From EMBRACE, GENEPSO, GEO-HEBON, and the IBCCS Collaborating Group J. Clin. Oncol., September 1, 2007; 25(25): 3831 - 3836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Choi, A. S. T. Wong, H.-F. Huang, and P. C. K. Leung Gonadotropins and Ovarian Cancer Endocr. Rev., June 1, 2007; 28(4): 440 - 461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Haile, D. C. Thomas, V. McGuire, A. Felberg, E. M. John, R. L. Milne, J. L. Hopper, M. A. Jenkins, A. J. Levine, M. M. Daly, et al. BRCA1 and BRCA2 Mutation Carriers, Oral Contraceptive Use, and Breast Cancer Before Age 50 Cancer Epidemiol. Biomarkers Prev., October 1, 2006; 15(10): 1863 - 1870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Loud, N. E. Weissman, J. A. Peters, R. M. Giusti, B. S. Wilfond, W. Burke, and M. H. Greene Deliberate Deceit of Family Members: A Challenge to Providers of Clinical Genetics Services J. Clin. Oncol., April 1, 2006; 24(10): 1643 - 1646. [Full Text] [PDF]
|
|
|
|
|
|
J. S. Lee, E. M. John, V. McGuire, A. Felberg, K. L. Ostrow, R. A. DiCioccio, F. P. Li, A. Miron, D. W. West, and A. S. Whittemore Breast and Ovarian Cancer in Relatives of Cancer Patients, with and without BRCA Mutations. Cancer Epidemiol. Biomarkers Prev., February 1, 2006; 15(2): 359 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. D. Nelson, L. H. Huffman, R. Fu, and E. L. Harris Genetic Risk Assessment and BRCA Mutation Testing for Breast and Ovarian Cancer Susceptibility: Systematic Evidence Review for the U.S. Preventive Services Task Force Ann Intern Med, September 6, 2005; 143(5): 362 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E M Rosen, S Fan, and C Isaacs BRCA1 in hormonal carcinogenesis: basic and clinical research Endocr. Relat. Cancer, September 1, 2005; 12(3): 533 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Whittemore, G. Gong, E. M. John, V. McGuire, F. P. Li, K. L. Ostrow, R. DiCioccio, A. Felberg, and D. W. West Prevalence of BRCA1 Mutation Carriers among U.S. Non-Hispanic Whites Cancer Epidemiol. Biomarkers Prev., December 1, 2004; 13(12): 2078 - 2083. [Abstract] [Full Text] [PDF]
|
|