Skip Navigation

American Journal of Epidemiology 2004 160(3):248-258; doi:10.1093/aje/kwh214
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (13)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Skinner, H. G.
Right arrow Articles by Fuchs, C. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Skinner, H. G.
Right arrow Articles by Fuchs, C. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 2004 by the Johns Hopkins Bloomberg School of Public Health

ORIGINAL CONTRIBUTIONS

A Prospective Study of Folate Intake and the Risk of Pancreatic Cancer in Men and Women

Halcyon G. Skinner1 , Dominique S. Michaud2, Edward L. Giovannucci2,3,4, Eric B. Rimm2,3,4, Meir J. Stampfer2,3,4, Walter C. Willett2,3,4, Graham A. Colditz2,3,4 and Charles S. Fuchs3,5

1 Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
2 Department of Epidemiology, Harvard School of Public Health, Boston, MA.
3 Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA.
4 Department of Nutrition, Harvard School of Public Health, Boston, MA.
5 Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA.

Laboratory and human studies suggest that folate intake may influence the risk of some cancers. However, prospective information about the relation between folate intake and the risk of exocrine pancreatic cancer is limited. The authors examined the relation of dietary folate intake to the risk of pancreatic cancer in two large prospective US cohorts. Folate intake was assessed by food frequency questionnaire in 1984 in women and in 1986 in men. Multivariate relative risks were adjusted for age, energy intake, cigarette smoking, body mass index, diabetes, and height. During 14 years’ follow-up in each cohort, 326 incident cases of pancreatic cancer were identified. Compared with participants in the lowest category of folate intake, participants in increasing 100-µg categories of total energy-adjusted folate intake had pooled multivariate relative risks for pancreatic cancer of 1.08, 1.10, and 1.03 (95% confidence interval: 0.74, 1.43; ptrend = 0.99). For energy-adjusted folate from food, the pooled relative risks for increasing 100-µg categories of intake were 0.81, 0.89, and 0.66 (95% confidence interval: 0.42, 1.03; ptrend = 0.12). There was no statistical interaction between folate intake and methionine, alcohol, fat, or caffeine. The results from these two large prospective cohorts do not support a strong association between energy-adjusted folate intake and the risk of pancreatic cancer.

adult; cohort studies; folic acid; human; nutrition assessment; pancreatic neoplasms; prospective studies

Abbreviations: Abbreviations: ATBC, Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study; CI, confidence interval; SE, standard error.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cancer Res.Home page
E. Schernhammer, B. Wolpin, N. Rifai, B. Cochrane, J. A. Manson, J. Ma, E. Giovannucci, C. Thomson, M. J. Stampfer, and C. Fuchs
Plasma Folate, Vitamin B6, Vitamin B12, and Homocysteine and Pancreatic Cancer Risk in Four Large Cohorts
Cancer Res., June 1, 2007; 67(11): 5553 - 5560.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
H. G. Skinner, D. S. Michaud, E. Giovannucci, W. C. Willett, G. A. Colditz, and C. S. Fuchs
Vitamin d intake and the risk for pancreatic cancer in two cohort studies.
Cancer Epidemiol. Biomarkers Prev., September 1, 2006; 15(9): 1688 - 1695.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
S. C. Larsson, N. Hakansson, E. Giovannucci, and A. Wolk
Folate intake and pancreatic cancer incidence: a prospective study of Swedish women and men.
J Natl Cancer Inst, March 15, 2006; 98(6): 407 - 413.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
D. Li, M. Ahmed, Y. Li, L. Jiao, T.-H. Chou, R. A. Wolff, R. Lenzi, D. B. Evans, M. L. Bondy, P. W. Pisters, et al.
5,10-Methylenetetrahydrofolate Reductase Polymorphisms and the Risk of Pancreatic Cancer
Cancer Epidemiol. Biomarkers Prev., June 1, 2005; 14(6): 1470 - 1476.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.