Am J Epidemiol 2004; 160:102-109.
Copyright © 2004 by the Johns
Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Periconceptional Dietary Intake of Choline and Betaine and Neural Tube Defects in Offspring
1 March of Dimes Birth Defects Foundation, California Birth Defects Monitoring Program, Berkeley, CA.
2 Division of Epidemiology and Biostatistics, University of California, Berkeley, Berkeley, CA.
3 Kaiser Permanente Care Management Institute, Oakland, CA.
Periconceptional intake of folic acid prevents some neural tube defects (NTDs). Other nutrients may also contribute to NTD etiologies; a likely candidate is choline. Similar to folic acid, choline is involved in one-carbon metabolism for methylation of homocysteine to methionine. The authors investigated whether maternal periconceptional dietary intakes of choline and its metabolite betaine influence NTD risk. Data were derived from a case-control study of fetuses and infants with NTDs among 1989–1991 California births. In-person interviews were conducted with mothers of 424 NTD cases and with mothers of 440 nonmalformed controls. A standard 100-item food frequency questionnaire was used to assess nutrient intake. Dietary intakes of choline were associated with reduced NTD risks. Controlling for intake of supplemental folic acid, dietary folate, dietary methionine, and other covariates did not substantially influence risk estimates for choline. NTD risk estimates were lowest for women whose diets were rich in choline, betaine, and methionine. That is, for women whose intake was above the 75th percentile compared with below the 25th percentile for all three nutrients, the odds ratio was 0.17 (95% confidence interval: 0.04, 0.76). Study findings for dietary components other than folic acid offer additional clues about the complex etiologies of NTDs.
abnormalities; case-control studies; folic acid; methionine; pregnancy; vitamins
Abbreviations: Abbreviations: CI, confidence interval; NTD, neural tube defect.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  X. Xu, M. D. Gammon, S. H. Zeisel, Y. L. Lee, J. G. Wetmur, S. L. Teitelbaum, P. T. Bradshaw, A. I. Neugut, R. M. Santella, and J. Chen Choline metabolism and risk of breast cancer in a population-based study FASEB J, June 1, 2008; 22(6): 2045 - 2052. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hung, C. M. Abratte, W. Wang, R. Li, D. J. Moriarty, and M. A. Caudill Ethnicity and Folate Influence Choline Status in Young Women Consuming Controlled Nutrient Intakes J. Am. Coll. Nutr., April 1, 2008; 27(2): 253 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Detopoulou, D. B Panagiotakos, S. Antonopoulou, C. Pitsavos, and C. Stefanadis Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study Am. J. Clinical Nutrition, February 1, 2008; 87(2): 424 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Solis, K. Veenema, A. A. Ivanov, S. Tran, R. Li, W. Wang, D. J. Moriarty, C. V. Maletz, and M. A. Caudill Folate Intake at RDA Levels Is Inadequate for Mexican American Men with the Methylenetetrahydrofolate Reductase 677TT Genotype J. Nutr., January 1, 2008; 138(1): 67 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Friesen, E. M. Novak, D. Hasman, and S. M. Innis Relationship of Dimethylglycine, Choline, and Betaine with Oxoproline in Plasma of Pregnant Women and Their Newborn Infants J. Nutr., December 1, 2007; 137(12): 2641 - 2646. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. P. Kovacheva, T. J. Mellott, J. M. Davison, N. Wagner, I. Lopez-Coviella, A. C. Schnitzler, and J. K. Blusztajn Gestational Choline Deficiency Causes Global and Igf2 Gene DNA Hypermethylation by Up-regulation of Dnmt1 Expression J. Biol. Chem., October 26, 2007; 282(43): 31777 - 31788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H Zeisel Nutrigenomics and metabolomics will change clinical nutrition and public health practice: insights from studies on dietary requirements for choline Am. J. Clinical Nutrition, September 1, 2007; 86(3): 542 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Cho, W. C. Willett, G. A. Colditz, C. S. Fuchs, K. Wu, A. T. Chan, S. H. Zeisel, and E. L. Giovannucci Dietary Choline and Betaine and the Risk of Distal Colorectal Adenoma in Women J Natl Cancer Inst, August 15, 2007; 99(16): 1224 - 1231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Ziegler and U. Lim One-Carbon Metabolism, Colorectal Carcinogenesis, Chemoprevention with Caution J Natl Cancer Inst, August 15, 2007; 99(16): 1214 - 1215. [Full Text] [PDF]
|
|
|
|
|
|
M. Resseguie, J. Song, M. D. Niculescu, K.-A. da Costa, T. A. Randall, and S. H. Zeisel Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes FASEB J, August 1, 2007; 21(10): 2622 - 2632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D Niculescu, K.-A. da Costa, L. M Fischer, and S. H Zeisel Lymphocyte gene expression in subjects fed a low-choline diet differs between those who develop organ dysfunction and those who do not Am. J. Clinical Nutrition, July 1, 2007; 86(1): 230 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M Fischer, K. A. daCosta, L. Kwock, P. W Stewart, T.-S. Lu, S. P Stabler, R. H Allen, and S. H Zeisel Sex and menopausal status influence human dietary requirements for the nutrient choline Am. J. Clinical Nutrition, May 1, 2007; 85(5): 1275 - 1285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Zeisel Response to: DEA in consumer products is safe FASEB J, January 1, 2007; 21(1): 296 - 297. [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Yuan, A. Tie, M. Tarnopolsky, and M. Bakovic Genomic organization, promoter activity, and expression of the human choline transporter-like protein 1 Physiol Genomics, September 14, 2006; 26(1): 76 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-A. da Costa, M. D Niculescu, C. N Craciunescu, L. M Fischer, and S. H Zeisel Choline deficiency increases lymphocyte apoptosis and DNA damage in humans Am. J. Clinical Nutrition, July 1, 2006; 84(1): 88 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-A. da Costa, O. G. Kozyreva, J. Song, J. A. Galanko, L. M. Fischer, and S. H. Zeisel Common genetic polymorphisms affect the human requirement for the nutrient choline FASEB J, July 1, 2006; 20(9): 1336 - 1344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. D. Rees, F. A. Wilson, and C. A. Maloney Sulfur Amino Acid Metabolism in Pregnancy: The Impact of Methionine in the Maternal Diet J. Nutr., June 1, 2006; 136(6): 1701S - 1705S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Michel, Z. Yuan, S. Ramsubir, and M. Bakovic Choline Transport for Phospholipid Synthesis. Experimental Biology and Medicine, May 1, 2006; 231(5): 490 - 504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cho, S. H Zeisel, P. Jacques, J. Selhub, L. Dougherty, G. A Colditz, and W. C Willett Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am. J. Clinical Nutrition, April 1, 2006; 83(4): 905 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kohlmeier, K.-A. da Costa, L. M. Fischer, and S. H. Zeisel Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans PNAS, November 1, 2005; 102(44): 16025 - 16030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H Zeisel Choline, homocysteine, and pregnancy Am. J. Clinical Nutrition, October 1, 2005; 82(4): 719 - 720. [Full Text] [PDF]
|
|
|
|
|
|
F. V Velzing-Aarts, P. I Holm, M R. Fokkema, F. P van der Dijs, P. M Ueland, and F. A Muskiet Plasma choline and betaine and their relation to plasma homocysteine in normal pregnancy Am. J. Clinical Nutrition, June 1, 2005; 81(6): 1383 - 1389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Ulrey, L. Liu, L. G. Andrews, and T. O. Tollefsbol The impact of metabolism on DNA methylation Hum. Mol. Genet., April 15, 2005; 14(suppl_1): R139 - R147. [Abstract] [Full Text] [PDF]
|
|