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American Journal of Epidemiology 2004 160(11):1039-1046; doi:10.1093/aje/kwh337
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Copyright © 2004 by the Johns Hopkins Bloomberg School of Public Health

ORIGINAL CONTRIBUTIONS

Higher Bone Mineral Density in Rural Compared with Urban Dwellers

The NOREPOS Study

H. E. Meyer1,2 , G. K. R. Berntsen3, A. J. Søgaard1, A. Langhammer4, B. Schei4, V. Fønnebø3, S. Forsmo4, G. S. Tell5 and the Norwegian Epidemiological Osteoporosis Studies (NOREPOS) Research Group

1 Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
2 Section for Preventive Medicine and Epidemiology, University of Oslo, Oslo, Norway.
3 Institute of Community Medicine, University of Tromsø, Tromsø, Norway.
4 Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.
5 Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway.

Norway has a very high incidence of osteoporotic fractures, with substantial regional differences in fracture incidence. The present study evaluated whether there are differences in bone mineral density (BMD) between regions in Norway with differences in fracture incidence. The authors used data collected in four large, population-based, multipurpose studies performed in four regions of Norway during 1994–2001. Distal forearm BMD was measured by single energy x-ray absorptiometry in 10,667 participants aged 40–75 years. Cross-calibration was performed by using the European Forearm Phantom. Mean distal forearm BMD was lower in the urban populations of Tromsø, Oslo, and Bergen compared with the rural county of Nord-Trøndelag, whereas there was no difference between the rural part of Tromsø and Nord-Trøndelag. For women, body mass index explained some of these differences. The prevalence of low BMD (z score ≤ –1) in Oslo, Bergen, and urban Tromsø, compared with Nord-Trøndelag, was 1.6–1.7 times higher in men and 1.5–2.0 times higher in women, whereas no significant difference was found between rural Tromsø and Nord-Trøndelag. In this study, higher BMD was found in rural compared with urban areas of Norway, which might help explain the differences in fracture incidence. There was no apparent north-south gradient in BMD.

bone density; cross-sectional studies; densitometry; forearm; fractures; men; osteoporosis; women

Abbreviations: Abbreviations: BMD, bone mineral density; CI, confidence interval.


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