Copyright © 2004 by the Johns Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Differential Distribution of Allelic Variants in Cytokine Genes among African Americans and White Americans
From the Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Racial disparities in health are largely unexplained. Because many diseases causing premature mortality among African Americans are mediated by the immune system, the authors explored the race-specific distribution of allelic variants in cytokine genes known to stimulate inflammation. The authors studied women seeking prenatal care and delivering singletons in uncomplicated first births at a US hospital in 1997–2001. A total of 179 African-American women and 396 White women were evaluated for functionally relevant allelic variants in cytokine genes. African-American women were significantly more likely to carry allelic variants known to up-regulate proinflammatory cytokines; odds ratios increased with allele dose. Odds ratios for African Americans versus Whites in genotypes up-regulating proinflammatory interleukin (IL) 1 (IL1A-4845G/G, IL1A-889T/T, IL1B-3957C/C, and IL1B-511A/A) ranged from 2.1 to 4.9. The proinflammatory cytokine interleukin-6 IL6-174 G/G genotype was 36.5 times (95% confidence interval (CI): 8.8, 151.9) more common among African Americans. Genotypes known to down-regulate the antiinflammatory interleukin-10 (IL10-819 T/T and IL10-1082 A/A) were elevated 3.5-fold (95% CI: 1.8, 6.6) and 2.8-fold (95% CI: 1.6, 4.9) in African Americans. Cytokine genotypes found to be more common in African-American women were consistently those that up-regulate inflammation.
continental population groups; cytokines; polymorphism (genetics)
Abbreviations:
Abbreviations: CI, confidence interval; IL, interleukin; IL1A, interleukin-1
; IL1B, interleukin-1ß; IL6, interleukin-6; IL10, interleukin-10; IL18, interleukin-18; OR, odds ratio; Th-1, T-helper type 1; TNFA, tumor necrosis factor-.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. L. Van Dyke, M. L. Cote, A. S. Wenzlaff, W. Chen, J. Abrams, S. Land, C. N. Giroux, and A. G. Schwartz Cytokine and Cytokine Receptor Single-Nucleotide Polymorphisms Predict Risk for Non-Small Cell Lung Cancer among Women Cancer Epidemiol. Biomarkers Prev., June 1, 2009; 18(6): 1829 - 1840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Chauhan and W McGuire Interleukin-6 (-174C) polymorphism and the risk of sepsis in very low birth weight infants: meta-analysis Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2008; 93(6): F427 - F429. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Hagel, M. Cabrera, E. Buvat, L. Gutierrez, C. Santaella, R. Borges, B. Infante, M. C. Salas, and Y. Barrios Antibody Responses and Resistance against Ascaris lumbricoides Infection among Venezuelan Rural Children: The Influence of Ethnicity J Trop Pediatr, October 1, 2008; 54(5): 354 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Barnato, S. L. Alexander, W. T. Linde-Zwirble, and D. C. Angus Racial Variation in the Incidence, Care, and Outcomes of Severe Sepsis: Analysis of Population, Patient, and Hospital Characteristics Am. J. Respir. Crit. Care Med., February 1, 2008; 177(3): 279 - 284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Evans, M. Collins, C. Jennings, L. van der Merwe, I. Soderstrom, T. Olsson, N. S Levitt, E. V Lambert, and J. H Goedecke The association of interleukin-18 genotype and serum levels with metabolic risk factors for cardiovascular disease Eur. J. Endocrinol., November 1, 2007; 157(5): 633 - 640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. Schempf, A. M. Branum, S. L. Lukacs, and K. C. Schoendorf The Contribution of Preterm Birth to the Black-White Infant Mortality Gap, 1990 and 2000 Am J Public Health, July 1, 2007; 97(7): 1255 - 1260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Kaplan, G. Y.F. Ho, X. Xue, S. Rajpathak, M. Cushman, T. E. Rohan, H. D. Strickler, P. E. Scherer, and K. Anastos Within-Individual Stability of Obesity-Related Biomarkers among Women Cancer Epidemiol. Biomarkers Prev., June 1, 2007; 16(6): 1291 - 1293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C. Barnes, A. V. Grant, N. N. Hansel, P. Gao, and G. M. Dunston African Americans with Asthma: Genetic Insights Proceedings of the ATS, January 1, 2007; 4(1): 58 - 68. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Hou, E.M. El-Omar, J. Chen, P. Grillo, C.S. Rabkin, A. Baccarelli, M. Yeager, S.J. Chanock, W. Zatonski, L.H. Sobin, et al. Polymorphisms in Th1-type cell-mediated response genes and risk of gastric cancer Carcinogenesis, January 1, 2007; 28(1): 118 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Jawa, M. N. Kulaylat, H. Baumann, and M. T. Dayton What Is New in Cytokine Research Related to Trauma/Critical Care J Intensive Care Med, March 1, 2006; 21(2): 63 - 85. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Chen, L. M. Wilkins, N. Aziz, C. Cannings, D. H. Wyllie, C. Bingle, J. Rogus, J. D. Beck, S. Offenbacher, M. J. Cork, et al. Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context Hum. Mol. Genet., February 15, 2006; 15(4): 519 - 529. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. C. Blackwell, S. M. Moscovis, A. E. Gordon, O. M. Al Madani, S. T. Hall, M. Gleeson, R. J. Scott, J. Roberts-Thomson, D. M. Weir, and A. Busuttil Cytokine responses and sudden infant death syndrome: genetic, developmental, and environmental risk factors J. Leukoc. Biol., December 1, 2005; 78(6): 1242 - 1254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Barnes Genetic Determinants and Ethnic Disparities in Sepsis-associated Acute Lung Injury Proceedings of the ATS, October 1, 2005; 2(3): 195 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Ness, S. L. Hillier, K. E. Kip, H. E. Richter, D. E. Soper, C. A. Stamm, J. A. McGregor, D. C. Bass, P. Rice, and R. L. Sweet Douching, Pelvic Inflammatory Disease, and Incident Gonococcal and Chlamydial Genital Infection in a Cohort of High-Risk Women Am. J. Epidemiol., January 15, 2005; 161(2): 186 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Cytokine Production, Race, and Allelic Variants Journal Watch Infectious Diseases, January 14, 2005; 2005(114): 12 - 12. [Full Text]
|
|