Am J Epidemiol 2004; 159:444-453.
Copyright © 2004 by the Johns
Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Alcohol Intake, Drinking Patterns, and Risk of Prostate Cancer in a Large Prospective Cohort Study
1 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
2 Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD.
3 Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD.
4 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
5 Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA.
6 Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA.
Alcohol drinking has been extensively studied in relation to prostate cancer, yet findings on the direction of the association are equivocal. Previous studies have not examined drinking patterns. Thus, the authors prospectively evaluated the associations between these factors and risk of incident prostate cancer (n = 2,479) in a cohort study of 47,843 US men (1986–1998). The men completed a questionnaire at baseline that included information on consumption of specific types of alcohol and frequency of use. The authors estimated hazard ratios using Cox proportional hazards regression for average alcohol intake and number of days per week on which alcohol was consumed stratified by average weekly intake (<105 g/week vs. 
105 g/week). Compared with nondrinking, the hazard ratio for consumption increased slightly from an average of 5.0–14.9 g/day (hazard ratio (HR) = 1.05, 95% confidence interval (CI): 0.94, 1.18) to 30.0–49.9 g/day (HR = 1.13, 95% CI: 0.96, 1.33), but it was not increased at 50 g/day (HR = 1.00, 95% CI: 0.77, 1.31) after adjustment for recent smoking and other factors. Compared with abstainers, risk was greatest among men who consumed an average of 105 g/week but who drank on only 1–2 days per week (HR = 1.64, 95% CI: 1.13, 2.38). These results suggest that moderate or greater alcohol consumption is not a strong contributor to prostate cancer risk, except possibly in men who consume large amounts infrequently.
alcohol drinking; cohort studies; ethanol; prostatic neoplasms; risk
Abbreviations: Abbreviations: CI, confidence interval; HR, hazard ratio.
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