Am J Epidemiol 2004; 159:351-357.
Copyright © 2004 by the Johns
Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Serum Vitamin Levels and the Risk of Asthma in Children
1 Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD.
2 Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Dietary intake, especially of antioxidant vitamins A, C, E, and the carotenoids, has been linked with the presence and severity of asthma. From the Third National Health and Nutrition Examination Survey (NHANES III), conducted in the United States between 1988 and 1994, the authors selected 4,093 children (aged 6–17 years) for whom relevant medical, socioeconomic, and anthropometric data were complete. The children were 50.6% female, and 9.7% reported a diagnosis of asthma. Bivariate analyses showed that asthma diagnosis was associated with lower levels of serum vitamin C, 
-carotene, ß-carotene, and ß-cryptoxanthin. However, antioxidant levels may be surrogate markers for socioeconomic variables such as race, poverty, tobacco exposure, or general nutritional status. In logistic models that included age, body mass index, socioeconomic variables, antioxidant levels, parental asthma, and household smoking, the only antioxidants significantly associated with asthma were vitamin C (odds ratio = 0.72 per mg/dl, 95% confidence interval = 0.55, 0.95) and -carotene (odds ratio = 0.95 per µg/dl, 95% confidence interval = 0.90, 0.99). The odds ratio for asthma in the highest quintile of serum vitamin C relative to the lowest was 0.65 (p < 0.05), whereas it was 0.74 for -carotene (p = 0.066). The authors concluded that low vitamin C and -carotene intakes are associated with asthma risk in children.
adolescent; antioxidants; ascorbic acid; asthma; child
Abbreviations: Abbreviation: NHANES III, Third National Health and Nutrition Examination Survey.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. R. Williams, M. Sternthal, and R. J. Wright Social Determinants: Taking the Social Context of Asthma Seriously Pediatrics, March 1, 2009; 123(Supplement_3): S174 - S184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ueki, G. Mahemuti, H. Oyamada, H. Kato, J. Kihara, M. Tanabe, W. Ito, T. Chiba, M. Takeda, H. Kayaba, et al. Retinoic Acids Are Potent Inhibitors of Spontaneous Human Eosinophil Apoptosis J. Immunol., December 1, 2008; 181(11): 7689 - 7698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Nadeem, A. Masood, and N. Siddiqui Review: Oxidant--antioxidant imbalance in asthma: scientific evidence, epidemiological data and possible therapeutic options Therapeutic Advances in Respiratory Disease, August 1, 2008; 2(4): 215 - 235. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Feary and J. Britton Dietary supplements and asthma: another one bites the dust Thorax, June 1, 2007; 62(6): 466 - 468. [Full Text] [PDF]
|
|
|
|
 |
|
 G. Riccioni, M. Barbara, T. Bucciarelli, C. di Ilio, and N. D'Orazio Antioxidant Vitamin Supplementation in Asthma Ann. Clin. Lab. Sci., January 1, 2007; 37(1): 96 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Devereux, S. W. Turner, L. C. A. Craig, G. McNeill, S. Martindale, P. J. Harbour, P. J. Helms, and A. Seaton Low Maternal Vitamin E Intake during Pregnancy Is Associated with Asthma in 5-Year-Old Children Am. J. Respir. Crit. Care Med., September 1, 2006; 174(5): 499 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Braganza and P. O. Ozuah Fad Therapies Pediatr. Rev., October 1, 2005; 26(10): 371 - 376. [Full Text] [PDF]
|
|
|
|
 |
|
 N. L. A. Misso, J. Brooks-Wildhaber, S. Ray, H. Vally, and P. J. Thompson Plasma concentrations of dietary and nondietary antioxidants are low in severe asthma Eur. Respir. J., August 1, 2005; 26(2): 257 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Martindale, G. McNeill, G. Devereux, D. Campbell, G. Russell, and A. Seaton Antioxidant Intake in Pregnancy in Relation to Wheeze and Eczema in the First Two Years of Life Am. J. Respir. Crit. Care Med., January 15, 2005; 171(2): 121 - 128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. McKeever and J. Britton Diet and Asthma Am. J. Respir. Crit. Care Med., October 1, 2004; 170(7): 725 - 729. [Full Text] [PDF]
|
|