Am J Epidemiol 2004; 159:49-58.
Copyright © 2004 by the Johns
Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Association of In Utero Exposure to Maternal Smoking with Reduced Semen Quality and Testis Size in Adulthood: A Cross-Sectional Study of 1,770 Young Men from the General Population in Five European Countries
1 Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.
2 Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark.
3 Clinics of Surgery, Tartu University Clinicum, Tartu, Estonia.
4 Department of Obstetrics and Gynecology, Rikshospitalet, Oslo, Norway.
5 Institute of Biomedicine, Departments of Anatomy, Physiology and Paediatrics, University of Turku, Turku, Finland.
6 Institute of Endocrinology, Kaunas University of Medicine, Kaunas, Lithuania.
7 Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark.
Between 1996 and 1999, the authors invited all young men from five European countries who were undergoing compulsory medical examination for possible military service to participate in a study on male reproductive health. The participation rate was 19% in two cities in Denmark (n = 889), 17% in Oslo, Norway (n = 221), 13% in Turku, Finland (n = 313), 14% in Kaunas, Lithuania (n = 157), and 19% in Tartu, Estonia (n = 190). Each man provided a semen sample, was examined by a physician, and, in collaboration with his mother, completed a questionnaire about general and reproductive health, current smoking habits, and exposure to smoking in utero. After adjustment for confounding factors, men exposed to smoking in utero had a reduction in sperm concentration of 20.1% (95% confidence interval (CI): 6.8, 33.5) and a reduction in total sperm count of 24.5% (95% CI: 9.5, 39.5) in comparison with unexposed men. Percentages of motile and morphologically normal sperm cells were 1.85 (95% CI: 0.46, 3.23) and 0.64 (95% CI: –0.02, 1.30) percentage points lower, respectively, among men exposed in utero, and exposed men had a 1.15-ml (95% CI: 0.66, 1.64) smaller testis size. The associations were present when data from the study centers were analyzed separately (though not in Lithuania, where only 1% of mothers smoked during pregnancy), although the strength of the association varied. Maternal smoking may have long-term implications for the reproductive health of the offspring. This is another good reason to advise pregnant women to avoid smoking.
pregnancy; prenatal exposure delayed effects; semen; smoking; spermatozoa; sperm count
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