Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (6)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Saunders, C. L.
Right arrow Articles by Barrett, J. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Saunders, C. L.
Right arrow Articles by Barrett, J. H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Am J Epidemiol 2004; 159:17-22.
Copyright © 2004 by the Johns Hopkins Bloomberg School of Public Health

ORIGINAL CONTRIBUTIONS

Flexible Matching in Case-Control Studies of Gene-Environment Interactions

Catherine L. Saunders and Jennifer H. Barrett 

From the Genetic Epidemiology Division, Cancer Research UK Clinical Centre at Leeds, Leeds, United Kingdom.

Because of the lack of power of case-control study designs to detect gene-environment interactions, flexible matching has recently been proposed as a method of improving efficiency. In this paper, the authors consider a large-sample approximation method that allows estimation of the most efficient matching strategy when genotype and exposure are either independent or associated. The authors provide tables of the sample sizes required to detect gene-environment interactions if this flexible matching strategy is followed, and they make brief comparisons with other study designs.

case-control studies; epidemiologic methods; interaction; research design; statistics


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Int J EpidemiolHome page
N. M Gatto, U. B Campbell, A. G Rundle, and H. Ahsan
Further development of the case-only design for assessing gene-environment interaction: evaluation of and adjustment for bias
Int. J. Epidemiol., October 1, 2004; 33(5): 1014 - 1024.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
T. Sturmer and H. Brenner
THE AUTHORS REPLY
Am. J. Epidemiol., June 1, 2004; 159(11): 1108 - 1108.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.