Am J Epidemiol 2003; 158:705-709.
Copyright © 2003 by Johns
Hopkins Bloomberg School of Public Health
PRACTICE OF EPIDEMIOLOGY |
Agreement between Maternal Self-reported Ethanol Intake and Tobacco Use During Pregnancy and Meconium Assays for Fatty Acid Ethyl Esters and Cotinine
1 Department of Pediatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, HI.
2 Department of Public Health Sciences and Epidemiology, University of Hawaii John A. Burns School of Medicine, Honolulu, HI.
Reliance on self-reported use of tobacco and intake of ethanol during pregnancy is associated with a high probability of error. Use of biological markers, or biomarkers, potentially offers a more valid method to assess exposure. Although cotinine is an established biomarker for tobacco use, there is no established biomarker for in utero ethanol exposure. Recent reports suggest that fatty acid ethyl esters (FAEE) could serve this purpose. To assess agreement between maternal self-reported tobacco use and ethanol intake during pregnancy and detection of metabolites associated with tobacco use (cotinine) and ethanol intake (FAEE), the authors studied maternal histories and meconium samples obtained in November–December 1999 from 436 consecutive mother-infant pairs at a large urban regional perinatal center in Honolulu, Hawaii. Cohen’s kappa coefficient and 95% confidence intervals were calculated. Moderate agreement was found between reported tobacco use during the third trimester and detected cotinine level (kappa = 0.53, 95% confidence interval: 0.39, 0.68); however, there was no agreement between reported ethanol intake during the third trimester and detected FAEE (kappa = –0.02, 95% confidence interval: –0.04, 0.00). No mother reporting ethanol intake during the third trimester had detectable FAEE. Findings support the need for additional refinement and validation of the use of FAEE as a biomarker for maternal ethanol intake.
alcoholic beverages; biological markers; pregnancy; tobacco
Abbreviations: Abbreviation: FAEE, fatty acid ethyl esters.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  W. B. Pittard III, J. N. Laditka, and S. B. Laditka Associations Between Maternal Age and Infant Health Outcomes Among Medicaid-Insured Infants in South Carolina: Mediating Effects of Socioeconomic Factors Pediatrics, July 1, 2008; 122(1): e100 - e106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Karaolis-Danckert, A. E Buyken, M. Kulig, A. Kroke, J. Forster, W. Kamin, A. Schuster, C. Hornberg, T. Keil, R. L Bergmann, et al. How pre- and postnatal risk factors modify the effect of rapid weight gain in infancy and early childhood on subsequent fat mass development: results from the Multicenter Allergy Study 90 Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1356 - 1364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. H. Flick, C. A. Cook, S. M. Homan, M. McSweeney, C. Campbell, and L. Parnell Persistent Tobacco Use During Pregnancy and the Likelihood of Psychiatric Disorders Am J Public Health, October 1, 2006; 96(10): 1799 - 1807. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hukkanen, P. Jacob III, and N. L. Benowitz Metabolism and Disposition Kinetics of Nicotine Pharmacol. Rev., March 1, 2005; 57(1): 79 - 115. [Abstract] [Full Text] [PDF]
|
|