Am J Epidemiol 2003; 158:609-616.
Copyright © 2003 by Johns
Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Menthol Cigarettes and Risk of Lung Cancer
1 Department of Epidemiology, Boston University School of Public Health, Boston, MA.
2 Slone Epidemiology Center, Boston University, Boston, MA.
3 Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA.
4 Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA.
5 Division of General Internal Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA.
The authors analyzed data from a multihospital case-control study in the eastern United States to evaluate the hypothesis that smoking menthol cigarettes increases lung cancer risk compared with smoking nonmenthol cigarettes. Subjects included cases with lung cancer and controls admitted for conditions unrelated to smoking who were aged 40–74 years, were interviewed from 1981 to 2000, and had smoked for 
20 years. Information was available on the brand and type of cigarette smoked most recently and for the longest time. Analyses were based on 643 cases and 4,110 controls for whom brand information was available for 60% of the total duration of smoking. Logistic regression was used to estimate the relative risk of lung cancer according to number of years of menthol cigarette use (>15, 1–15, 0), adjusting for demographic and smoking-related factors. The lung cancer risk for long-term smokers of menthol cigarettes was similar to that for smokers of nonmenthol cigarettes (odds ratio = 0.97, 95% confidence interval: 0.70, 1.34). Odds ratios were also close to 1.0 in separate analyses of male, female, Black, and White subjects. The results of this study do not support the hypothesis that smoking menthol cigarettes increases the risk of lung cancer relative to smoking nonmenthol cigarettes.
Blacks; case-control studies; lung neoplasms; menthol; smoking; Whites
Abbreviations: Abbreviations: CI, confidence interval; OR, odds ratio.
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