Am J Epidemiol 2003; 158:195-202.
Copyright © 2003 by Johns
Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Symptoms of Wheeze and Persistent Cough in the First Year of Life: Associations with Indoor Allergens, Air Contaminants, and Maternal History of Asthma
1 Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT.
2 Occupational Medicine Division, Department of Environmental Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY.
3 Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Boston, MA.
4 Pulmonary Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
5 Department of Medicine, Division of Allergy and Immunology, University of Virginia Medical Center, Charlottesville, VA.
In a cohort of 849 infants with an asthmatic sibling, the authors examined the relations of exposure to allergens (dust mite, cockroach, cat, and dog), nitrogen dioxide, and mold with symptoms of wheeze and persistent cough in the first year of life (1998–2000). Among infants whose mothers had physician-diagnosed asthma, neither dust mite allergen nor dog allergen was associated with either symptom. Exposure to cockroach allergen (Bla g 1 at 
2 U/g) modestly increased the risk for wheeze (odds ratio (OR) = 1.87, 95% confidence interval (CI): 0.94, 3.71), and exposure to cat allergen modestly decreased the risk (OR = 0.60, 95% CI: 0.35, 1.03). Among infants of mothers with no asthma history, exposure to gas stoves (OR = 1.50, 95% CI: 1.05, 2.15) and wood-burning stoves (OR = 2.09, 95% CI: 1.12, 3.91) increased the risk of persistent cough. Similarly, measured nitrogen dioxide concentration was associated with persistent cough (OR = 1.21, 95% CI: 1.05, 1.40). Persistent mold affected both infants of mothers with asthma (for wheeze, OR = 2.27, 95% CI: 1.27, 4.07; for cough, OR = 1.83, 95% CI: 1.04, 3.22) and infants of mothers without asthma (for cough, OR = 1.55, 95% CI: 1.04, 2.31). Reported exposure was confirmed by an association of measured fungi with wheeze (OR = 1.23, 95% CI: 1.01, 1.49). This appears to have been the first study to measure all of these home exposures (indoor allergens, nitrogen dioxide, fungi) and to prospectively measure the frequency of infant wheeze and persistent cough.
allergens; cockroaches; cough; dust; fungi; infant; nitrogen dioxide; respiratory sounds
Abbreviations: Abbreviations: CI, confidence interval; OR, odds ratio.
CiteULike 
Connotea 
Del.icio.us What's this?
Related articles in Am. J. Epidemiol.:
- Invited Commentary: Is Indoor Mold Exposure a Risk Factor for Asthma?
- Jeroen Douwes and Neil Pearce
Am. J. Epidemiol. 2003 158: 203-206.[Extract] [FREE Full Text]
This article has been cited by other articles:
|
|
 |
|
  A. Ozkutuk, E. Ceylan, G. Ergor, M. Yucesoy, O. Itil, S. Caymaz, and A. Cimrin The Relationship between Moulds Isolated from Indoor Air and Features of the House Environment Indoor and Built Environment, June 1, 2008; 17(3): 269 - 273. [Abstract] [PDF]
|
|
|
|
 |
|
 N. P. Ly, M. E. Soto-Quiros, L. Avila, G. M. Hunninghake, B. A. Raby, D. Laskey, J. S. Sylvia, and J. C. Celedon Paternal Asthma, Mold Exposure, and Increased Airway Responsiveness Among Children With Asthma in Costa Rica Chest, January 1, 2008; 133(1): 107 - 114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Weichenthal, A. Dufresne, and C. Infante-Rivard Review: Indoor Nitrogen Dioxide and VOC Exposures: Summary of Evidence for an Association with Childhood Asthma and a Case for the Inclusion of Indoor Ultrafine Particle Measures in Future Studies Indoor and Built Environment, October 1, 2007; 16(5): 387 - 399. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Pekkanen, A. Hyvarinen, U. Haverinen-Shaughnessy, M. Korppi, T. Putus, and A. Nevalainen Moisture damage and childhood asthma: a population-based incident case-control study Eur. Respir. J., March 1, 2007; 29(3): 509 - 515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Committee on Environmental Health Spectrum of Noninfectious Health Effects From Molds Pediatrics, December 1, 2006; 118(6): 2582 - 2586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Mazur, J. Kim, and the Committee on Environmental Health Spectrum of Noninfectious Health Effects From Molds Pediatrics, December 1, 2006; 118(6): e1909 - e1926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Belanger, J. F. Gent, E. W. Triche, M. B. Bracken, and B. P. Leaderer Association of Indoor Nitrogen Dioxide Exposure with Respiratory Symptoms in Children with Asthma Am. J. Respir. Crit. Care Med., February 1, 2006; 173(3): 297 - 303. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Simoni, E Lombardi, G Berti, F Rusconi, S La Grutta, S Piffer, M G Petronio, C Galassi, F Forastiere, G Viegi, et al. Mould/dampness exposure at home is associated with respiratory disorders in Italian children and adolescents: the SIDRIA-2 Study Occup. Environ. Med., September 1, 2005; 62(9): 616 - 622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M Samet and M. L Bell Commentary: Nitrogen dioxide and asthma redux Int. J. Epidemiol., February 1, 2004; 33(1): 215 - 216. [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Gent, E. W. Triche, T. R. Holford, K. Belanger, M. B. Bracken, W. S. Beckett, and B. P. Leaderer Association of Low-Level Ozone and Fine Particles With Respiratory Symptoms in Children With Asthma JAMA, October 8, 2003; 290(14): 1859 - 1867. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Douwes and N. Pearce Invited Commentary: Is Indoor Mold Exposure a Risk Factor for Asthma? Am. J. Epidemiol., August 1, 2003; 158(3): 203 - 206. [Full Text] [PDF]
|
|