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Am J Epidemiol 2003; 158:942-946.
Copyright © 2003 by Johns Hopkins Bloomberg School of Public Health

ORIGINAL CONTRIBUTIONS

Consanguinity and Apnea of Prematurity

Hala Tamim1, Mustafa Khogali2, Hind Beydoun3, Imad Melki4, Khalid Yunis5  and the National Collaborative Perinatal Neonatal Network

1 Department of Epidemiology and Population Health, American University of Beirut, Beirut, Lebanon.
2 Department of Family Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
3 Social Statistics Section, United Nations Economic and Social Commission for Western Asia, Beirut, Lebanon.
4 Department of Pediatrics, Hotel Dieu de France Hospital, Beirut, Lebanon.
5 Department of Pediatrics, American University of Beirut Medical Center, Beirut, Lebanon.

Consanguinity, marriage between relatives, has been associated with perinatal mortality and morbidity. Apnea of prematurity is defined as the cessation of breathing for longer than 20 seconds or that of any duration if accompanied by cyanosis and sinus bradycardia, for infants born before 37 weeks of gestation. The objective of the study was to examine the association between consanguinity and apnea of prematurity in Greater Beirut, an area having a relatively high prevalence rate of consanguineous marriages. The study was cross-sectional. Between September 1, 1998, and March 31, 2001, 21,723 newborn infants were admitted to the National Collaborative Perinatal Neonatal Network in Greater Beirut, Lebanon. The inclusion criteria were infants less than 37 weeks of gestation who were admitted to the intensive care unit, with no congenital malformations, sepsis, or neurologic disorders. Analysis was based on 597 infants of whom 66 had apnea of prematurity. With adjustment for weeks and type of gestation, pregnancy complications, and Apgar score, the odds ratio of apnea of prematurity for first-degree consanguineous parents as compared with other marriages was 2.9 (95% confidence interval: 1.3, 6.4). In addition to the recognized etiologic factors for apnea of prematurity, this study suggests a role played by genetic factors.

apnea; consanguinity; infant, premature

Abbreviations: Abbreviation: NCPNN, National Collaborative Perinatal Neonatal Network.


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K. Yunis, R. E. Rafei, and G. Mumtaz
International Perspectives: Consanguinity: Perinatal Outcomes and Prevention - A View from the Middle East
NeoReviews, February 1, 2008; 9(2): e59 - e65.
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