Am J Epidemiol 2003; 157:800-814.
Copyright © 2003 by Johns
Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Use of Agricultural Pesticides and Prostate Cancer Risk in the Agricultural Health Study Cohort
1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
2 Department of Epidemiology, University of Iowa, Iowa City, IA.
3 Battelle/Centers for Public Health Research and Evaluation, Durham, NC.
4 US Environmental Protection Agency, Research Triangle Park, NC.
5 National Institute for Environmental Health Sciences, Research Triangle Park, NC.
6 IMS, Inc., Silver Spring, MD.
The authors examined the relation between 45 common agricultural pesticides and prostate cancer incidence in a prospective cohort study of 55,332 male pesticide applicators from Iowa and North Carolina with no prior history of prostate cancer. Data were collected by means of self-administered questionnaires completed at enrollment (1993–1997). Cancer incidence was determined through population-based cancer registries from enrollment through December 31, 1999. A prostate cancer standardized incidence ratio was computed for the cohort. Odds ratios were computed for individual pesticides and for pesticide use patterns identified by means of factor analysis. A prostate cancer standardized incidence ratio of 1.14 (95% confidence interval: 1.05, 1.24) was observed for the Agricultural Health Study cohort. Use of chlorinated pesticides among applicators over 50 years of age and methyl bromide use were significantly associated with prostate cancer risk. Several other pesticides showed a significantly increased risk of prostate cancer among study subjects with a family history of prostate cancer but not among those with no family history. Important family history-pesticide interactions were observed.
agrochemicals; fungicides, industrial; herbicides; insecticides; pesticides; prostatic neoplasms; risk
Abbreviations: Abbreviations: CI, confidence interval; DDT, dichlorodiphenyltrichloroethane; EPTC, S-ethyl dipropylthiocarbamate; OR, odds ratio; SIR, standardized incidence ratio; 2,4,5-T, 2,4,5-trichlorophenoxyacetic acid; 2,4,5-TP, 2,4,5-trichlorophenoxypropionic acid.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. Diamanti-Kandarakis, J.-P. Bourguignon, L. C. Giudice, R. Hauser, G. S. Prins, A. M. Soto, R. T. Zoeller, and A. C. Gore Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement Endocr. Rev., June 1, 2009; 30(4): 293 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S Prins Endocrine disruptors and prostate cancer risk Endocr. Relat. Cancer, September 1, 2008; 15(3): 649 - 656. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Bekkering, R. J. Harris, S. Thomas, A.-M. B. Mayer, R. Beynon, A. R. Ness, R. M. Harbord, C. Bain, G. D. Smith, and J. A. C. Sterne How Much of the Data Published in Observational Studies of the Association between Diet and Prostate or Bladder Cancer Is Usable for Meta-Analysis? Am. J. Epidemiol., May 1, 2008; 167(9): 1017 - 1026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Bonner, J. Coble, A. Blair, L. E. Beane Freeman, J. A. Hoppin, D. P. Sandler, and M. C. R. Alavanja Malathion Exposure and the Incidence of Cancer in the Agricultural Health Study Am. J. Epidemiol., November 1, 2007; 166(9): 1023 - 1034. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.L. Bassil, C. Vakil, M. Sanborn, D.C. Cole, J.S. Kaur, and K.J. Kerr Cancer health effects of pesticides: Systematic review Can Fam Physician, October 1, 2007; 53(10): 1704 - 1711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Rafnsson Farming and prostate cancer Occup. Environ. Med., March 1, 2007; 64(3): 143 - 143. [Full Text] [PDF]
|
|
|
|
|
|
T. E Meyer, A. L Coker, M. Sanderson, and E. Symanski A case-control study of farming and prostate cancer in African-American and Caucasian men Occup. Environ. Med., March 1, 2007; 64(3): 155 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Beane Freeman, M. R. Bonner, A. Blair, J. A. Hoppin, D. P. Sandler, J. H. Lubin, M. Dosemeci, C. F. Lynch, C. Knott, and M. C. R. Alavanja Cancer Incidence among Male Pesticide Applicators in the Agricultural Health Study Cohort Exposed to Diazinon Am. J. Epidemiol., December 1, 2005; 162(11): 1070 - 1079. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Cocco, D. Fadda, B. Billai, M. D'Atri, M. Melis, and A. Blair Cancer Mortality among Men Occupationally Exposed to Dichlorodiphenyltrichloroethane Cancer Res., October 15, 2005; 65(20): 9588 - 9594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Boers, M P A Zeegers, G M Swaen, I. Kant, and P A van den Brandt The influence of occupational exposure to pesticides, polycyclic aromatic hydrocarbons, diesel exhaust, metal dust, metal fumes, and mineral oil on prostate cancer: a prospective cohort study Occup. Environ. Med., August 1, 2005; 62(8): 531 - 537. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Engel, D. A. Hill, J. A. Hoppin, J. H. Lubin, C. F. Lynch, J. Pierce, C. Samanic, D. P. Sandler, A. Blair, and M. C. Alavanja Pesticide Use and Breast Cancer Risk among Farmers' Wives in the Agricultural Health Study Am. J. Epidemiol., January 15, 2005; 161(2): 121 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Lee, A. Blair, J. A. Hoppin, J. H. Lubin, J. A. Rusiecki, D. P. Sandler, M. Dosemeci, and M. C. R. Alavanja Cancer Incidence Among Pesticide Applicators Exposed to Chlorpyrifos in the Agricultural Health Study J Natl Cancer Inst, December 1, 2004; 96(23): 1781 - 1789. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Rusiecki, A. De Roos, W. J. Lee, M. Dosemeci, J. H. Lubin, J. A. Hoppin, A. Blair, and M. C. R. Alavanja Cancer Incidence Among Pesticide Applicators Exposed to Atrazine in the Agricultural Health Study J Natl Cancer Inst, September 15, 2004; 96(18): 1375 - 1382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. C-H Chiu, D. D. Weisenburger, S. H. Zahm, K. P. Cantor, S. M. Gapstur, F. Holmes, L. F. Burmeister, and A. Blair Agricultural Pesticide Use, Familial Cancer, and Risk of Non-Hodgkin Lymphoma Cancer Epidemiol. Biomarkers Prev., April 1, 2004; 13(4): 525 - 531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. Lee, J. A. Hoppin, A. Blair, J. H. Lubin, M. Dosemeci, D. P. Sandler, and M. C. R. Alavanja Cancer Incidence among Pesticide Applicators Exposed to Alachlor in the Agricultural Health Study Am. J. Epidemiol., February 15, 2004; 159(4): 373 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Hu, M. C. Hall, L. Grossman, M. Hedayati, D. L. McCullough, K. Lohman, and L. D. Case Deficient Nucleotide Excision Repair Capacity Enhances Human Prostate Cancer Risk Cancer Res., February 1, 2004; 64(3): 1197 - 1201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 OTHER ARTICLES NOTED (25 Apr 2003 to 18 Jul 2003) Evid. Based Nurs., October 1, 2003; 6(4): e1 - 12. [Full Text]
|
|