Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (17)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Hernández-Díaz, S.
Right arrow Articles by Mitchell, A. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hernández-Díaz, S.
Right arrow Articles by Mitchell, A. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Am J Epidemiol 2002; 156:806-812.
Copyright © 2002 by Johns Hopkins Bloomberg School of Public Health

ORIGINAL CONTRIBUTIONS

Risk of Gestational Hypertension in Relation to Folic Acid Supplementation during Pregnancy

Sonia Hernández-Díaz, Martha M. Werler, Carol Louik and Allen A. Mitchell

From the Slone Epidemiology Center, Boston University School of Public Health, Boston, MA.

The authors investigated the association between folic acid supplementation and gestational hypertension. The study population included women with nonmalformed infants in the United States and Canada who were participating in the Slone Epidemiology Center Birth Defects Study between 1993 and 2000. Women were interviewed within 6 months after delivery about sociodemographic and medical factors, the occurrence of hypertension with or without preeclampsia, and multivitamin use in pregnancy. Relative risks, adjusted for weight, parity, twin pregnancy, diabetes, smoking, education, and family income, were estimated using Cox regression models. Of 2,100 women, 204 (9.7%) reported gestational hypertension (onset after the 20th week of gestation). The multivariate-adjusted relative risk of developing gestational hypertension during the month after folic acid supplementation, compared with not using folic acid during that same month, was 0.55 (95% confidence interval: 0.39, 0.79). This finding suggests that folic acid-containing multivitamins may reduce the risk of gestational hypertension.

folic acid; hypertension; pre-eclampsia; pregnancy; vitamins

Abbreviations: Abbreviations: CI, confidence interval; RR, relative risk.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
R. M. Nilsen, S. E. Vollset, S. A. Rasmussen, P. M. Ueland, and A. K. Daltveit
Folic Acid and Multivitamin Supplement Use and Risk of Placental Abruption: A Population-based Registry Study
Am. J. Epidemiol., April 1, 2008; 167(7): 867 - 874.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
R. M Nilsen, S. E Vollset, H. K Gjessing, P. Magnus, H. M Meltzer, M. Haugen, and P. M Ueland
Patterns and predictors of folic acid supplement use among pregnant women: the Norwegian Mother and Child Cohort Study.
Am. J. Clinical Nutrition, November 1, 2006; 84(5): 1134 - 1141.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
H. Refsum, E. Nurk, A. D. Smith, P. M. Ueland, C. G. Gjesdal, I. Bjelland, A. Tverdal, G. S. Tell, O. Nygard, and S. E. Vollset
The Hordaland Homocysteine Study: A Community-Based Study of Homocysteine, Its Determinants, and Associations with Disease
J. Nutr., June 1, 2006; 136(6): 1731S - 1740S.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.