Am J Epidemiol 2002; 156:548-555.
Copyright © 2002 by the
Johns Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Exposure to Residential Radon and Lung Cancer in Spain: A Population-based Case-Control Study
1 Department of Preventive Medicine and Public Health, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain.
2 Preventive Medicine Unit, Santiago de Compostela University Teaching Hospital, Santiago de Compostela, Spain.
Although high radon concentrations have been linked to increased risk of lung cancer by both experimental studies and investigations of underground miners, epidemiologic studies of residential radon exposure display inconsistencies. The authors therefore decided to conduct a population-based case-control study in northwest Spain to determine the risk of lung cancer associated with exposure to residential radon. The study covered a total of 163 subjects with incident lung cancer and a population sample of 241 cancer-free subjects since 1992–1994. Odds ratios for radon were estimated using logistic regression adjusted for sex, age, lifetime tobacco use, family history, and habitat. The adjusted odds ratios for the second, third, and fourth quartiles of radon (breakpoints: 37.0, 55.2, and 148.0 Bq/m3) were 2.73 (95% confidence interval (CI): 1.12, 5.48), 2.48 (95% CI: 1.29, 6.79), and 2.96 (95% CI: 1.29, 6.79), respectively. An additive synergic effect between radon and tobacco was found. The results from this study suggest that, even at concentrations far below official guideline levels, radon may lead to a 2.5-fold rise in the risk of lung cancer. Furthermore, the synergy found between smoking and radon may prove useful when it comes to drafting public health recommendations.
case-control studies; lung neoplasms; radon
Abbreviations: Abbreviation: CI, confidence interval.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Ruano-Ravina, R. Perez-Becerra, M. Fraga, K. T. Kelsey, and J. M. Barros-Dios Analysis of the relationship between p53 immunohistochemical expression and risk factors for lung cancer, with special emphasis on residential radon exposure Ann. Onc., January 1, 2008; 19(1): 109 - 114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Darby, D Hill, A Auvinen, J M Barros-Dios, H Baysson, F Bochicchio, H Deo, R Falk, F Forastiere, M Hakama, et al. Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies BMJ, January 29, 2005; 330(7485): 223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Boffetta and F. Nyberg Contribution of environmental factors to cancer risk Br. Med. Bull., December 1, 2003; 68(1): 71 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 RE: "EXPOSURE TO RESIDENTIAL RADON AND LUNG CANCER IN SPAIN: A POPULATION-BASED CASE-CONTROL STUDY" Am. J. Epidemiol., May 1, 2003; 157(9): 859 - 859. [Full Text] [PDF]
|
|