Am J Epidemiol 2002; 156:507-516.
Copyright © 2002 by the
Johns Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Risk of Breast Cancer Classified by Joint Estrogen Receptor and Progesterone Receptor Status among Women 20–44 Years of Age
1 Division of Environmental Health Science, Mount Sinai School of Medicine, New York, NY.
2 Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC.
3 Cancer Epidemiology Services at the New Jersey Department of Health and Senior Services, Trenton, NJ.
4 Fred Hutchinson Cancer Research Center/University of Washington, Seattle, WA.
5 Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA.
6 Office of Dietary Supplements, National Institutes of Health, Bethesda, MD.
7 Applied Research Branch, National Cancer Institute, Bethesda, MD.
8 Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA.
9 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
To gain insight into whether breast cancer tumors jointly classified by estrogen receptor (ER) and progesterone receptor (PR) status represent diseases with differing etiologies, data from a population-based case-control study of US women 20–44 years of age were analyzed. Cases included 1,556 women diagnosed between 1990 and 1992. Age- and geographic-frequency-matched controls included 1,397 women identified by random digit dialing. Heterogeneity between ER+PR+ and ER–PR– tumors was most pronounced in relation to age, race, and recreational exercise at 12–13 years of age. Multivariate-adjusted odds ratios for ER+PR+ tumors were 0.64 (95% confidence interval (CI): 0.47, 0.89) for 30–34 versus 40–44 years of age, 0.89 (95% CI: 0.63, 1.25) for Black versus White race, and 0.84 (95% CI: 0.68, 1.03) for exercise at 12–13 years of age above versus at or below the median. Corresponding odds ratios for ER–PR– tumors were 1.24 (95% CI: 0.86, 1.77), 1.51 (95% CI: 1.07, 2.14), and 1.15 (95% CI: 0.90, 1.48). Risk of ER–PR– cancer in relation to menstrual and reproductive (parity and lactation) characteristics, alcohol consumption, and family history of breast cancer was similar to that observed for ER+PR+ tumors. These findings only modestly support the hypothesis that hormonally related risk factors have differing relations with ER+PR+ versus ER–PR– tumors among younger women.
breast neoplasms; case-control studies; receptors, estrogen; receptors, progesterone; risk factors
Abbreviations: Abbreviations: BMI, body mass index; CI, confidence interval; ER, estrogen receptor; PR, progesterone receptor; WHR, waist-to-hip ratio.
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