Am J Epidemiol 2002; 156:445-453.
Copyright © 2002 by the
Johns Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Risk Factors for Alzheimer’s Disease: A Prospective Analysis from the Canadian Study of Health and Aging
1 Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
2 Surveillance and Risk Assessment Division, Health Canada, Ottawa, ON, Canada.
3 Laval University Geriatric Research Unit, Beauport, QC, Canada.
4 Department of Social and Preventive Medicine, Laval University, Quebec, QC, Canada.
5 Sherbrooke University Geriatric Institute, Sherbrooke, QC, Canada.
6 Elisabeth Bruyère Health Centre, Ottawa, ON, Canada.
A prospective analysis of risk factors for Alzheimer’s disease was a major objective of the Canadian Study of Health and Aging, a nationwide, population-based study. Of 6,434 eligible subjects aged 65 years or older in 1991, 4,615 were alive in 1996 and participated in the follow-up study. All participants were cognitively normal in 1991 when they completed a risk factor questionnaire. Their cognitive status was reassessed 5 years later by using a similar two-phase procedure, including a screening interview, followed by a clinical examination when indicated. The analysis included 194 Alzheimer’s disease cases and 3,894 cognitively normal controls. Increasing age, fewer years of education, and the apolipoprotein E 
4 allele were significantly associated with increased risk of Alzheimer’s disease. Use of nonsteroidal anti-inflammatory drugs, wine consumption, coffee consumption, and regular physical activity were associated with a reduced risk of Alzheimer’s disease. No statistically significant association was found for family history of dementia, sex, history of depression, estrogen replacement therapy, head trauma, antiperspirant or antacid use, smoking, high blood pressure, heart disease, or stroke. The protective associations warrant further study. In particular, regular physical activity could be an important component of a preventive strategy against Alzheimer’s disease and many other conditions.
Alzheimer disease; anti-inflammatory agents, non-steroidal; apolipoproteins; cohort studies; education; exercise; risk factors; wine
Abbreviations:
Abbreviations: APOE, apolipoprotein E; APOE4, apolipoprotein E 4 allele; CI, confidence interval; CSHA, Canadian Study of Health and Aging; EURODEM, European Community Concerted Action on Epidemiology and Prevention of Dementia; NSAIDs, nonsteroidal anti-inflammatory drugs; OR, odds ratio; 3MS, Modified Mini-Mental State.
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|
|
|
|
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|
|
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|
|
|
|
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|
|
|
|
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|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
MRC Cognitive Function and Ageing Study, A. G. Yip, C. Brayne, and F. E. Matthews Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study Age Ageing, March 1, 2006; 35(2): 154 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
 |
|
 P. Marambaud, H. Zhao, and P. Davies Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-{beta} Peptides J. Biol. Chem., November 11, 2005; 280(45): 37377 - 37382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
|
|
A. J. M. de Craen, J. Gussekloo, B. Vrijsen, and R. G. J. Westendorp Meta-Analysis of Nonsteroidal Antiinflammatory Drug Use and Risk of Dementia Am. J. Epidemiol., January 15, 2005; 161(2): 114 - 120. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Huang, C. Qiu, E. von Strauss, B. Winblad, and L. Fratiglioni APOE Genotype, Family History of Dementia, and Alzheimer Disease Risk: A 6-Year Follow-up Study Arch Neurol, December 1, 2004; 61(12): 1930 - 1934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-Y. R. Hsiung, A. D. Sadovnick, and H. Feldman Apolipoprotein E {epsilon}4 genotype as a risk factor for cognitive decline and dementia: data from the Canadian Study of Health and Aging Can. Med. Assoc. J., October 12, 2004; 171(8): 863 - 867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Abbott, L. R. White, G. W. Ross, K. H. Masaki, J. D. Curb, and H. Petrovitch Walking and Dementia in Physically Capable Elderly Men JAMA, September 22, 2004; 292(12): 1447 - 1453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. K. Srikanth, J. F.I. Anderson, G. A. Donnan, M. M. Saling, E. Didus, R. Alpitsis, H. M. Dewey, R. A.L. Macdonell, and A. G. Thrift Progressive dementia after first-ever stroke: A community-based follow-up study Neurology, September 14, 2004; 63(5): 785 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Anttila, E.-L. Helkala, M. Viitanen, I. Kareholt, L. Fratiglioni, B. Winblad, H. Soininen, J. Tuomilehto, A. Nissinen, and M. Kivipelto Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study BMJ, September 4, 2004; 329(7465): 539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Kramer, L. Bherer, S. J. Colcombe, W. Dong, and W. T. Greenough Environmental Influences on Cognitive and Brain Plasticity During Aging J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2004; 59(9): M940 - M957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Winkelman Genomics: What Every Critical Care Nurse Needs to Know About the Genetic Contribution to Critical Illness Crit. Care Nurse, June 1, 2004; 24(3): 34 - 45. [Full Text] [PDF]
|
|
|
|
 |
|
 J E Abell, J M Hootman, and C G Helmick Prevalence and impact of arthritis among nursing home residents Ann Rheum Dis, May 1, 2004; 63(5): 591 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hestiantoro and D. F. Swaab Changes in Estrogen Receptor-{alpha} and -{beta} in the Infundibular Nucleus of the Human Hypothalamus Are Related to the Occurrence of Alzheimer's Disease Neuropathology J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1912 - 1925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Qiu, B. Winblad, J. Fastbom, and L. Fratiglioni Combined effects of APOE genotype, blood pressure, and antihypertensive drug use on incident AD Neurology, September 9, 2003; 61(5): 655 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Etminan, S. Gill, and A. Samii Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies BMJ, July 17, 2003; 327(7407): 128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.L. Barnes, R.S. Wilson, J.A. Schneider, J.L. Bienias, D.A. Evans, and D.A. Bennett Gender, cognitive decline, and risk of AD in older persons Neurology, June 10, 2003; 60(11): 1777 - 1781. [Abstract] [Full Text] [PDF]
|
|