Am J Epidemiol 2002; 156:349-352.
Copyright © 2002 by the
Johns Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Serum Insulin and Glucose Levels and Breast Cancer Incidence
The Atherosclerosis Risk in Communities Study
1 Division of Cancer Prevention and Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
2 Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN.
3 Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.
4 Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.
The authors examined the association of breast cancer incidence with serum levels of insulin and glucose in a cohort of 7,894 women aged 45–64 years from four US communities. Anthropometric factors and fasting levels of insulin and glucose were measured at baseline (1987–1989). Over an average follow-up period of 7.1 years (1987–1995), 187 breast cancer cases were ascertained. Breast cancer was associated positively with body mass index but not with waist:hip ratio or serum insulin level. After adjustment for age, race, and study site, the incidence of breast cancer was 60% higher among diabetic women than among women with fasting glucose levels under 100 mg/dl, but this association was attenuated after further adjustment for body mass index and other covariates (adjusted rate ratio = 1.39, 95% confidence interval: 0.86, 2.23). Circulating insulin levels were not predictive of future breast cancer incidence, but there may be a weak association with type 2 diabetes, perhaps modulated via increased adiposity.
breast neoplasms; glucose; insulin
Abbreviations: Abbreviation: ARIC, Atherosclerosis Risk in Communities.
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