Am J Epidemiol 2002; 156:274-285.
Copyright © 2002 by the
Johns Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Factors Associated with Oxidative Stress in Human Populations
1 Division of Health Policy and Management, School of Public Health, University of California, Berkeley, CA.
2 Department of Biomedical Research, Our Lady of Mercy Medical Center, Bronx, NY.
3 Departments of Medicine and Pharmacology, School of Medicine, Vanderbilt University, Nashville, TN.
4 Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA.
5 Division of Research, Kaiser Permanente, Oakland, CA.
6 Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA.
Oxidation of biomolecules may play a role in susceptibility to a number of diseases. However, there are few large-scale survey data describing oxidative damage that occurs in humans and the demographic, physical, or nutritional factors that may be associated with it. Such information is essential for the design and analysis of studies investigating the role of oxidative stress in health and disease. This paper presents data on levels of two biomarkers of lipid peroxidation, malondialdehyde and F2-isoprostanes, in 298 healthy adults aged 19–78 years. The study was conducted in Berkeley and Oakland, California, in 1998–1999. Sex was the strongest predictor of lipid peroxidation as measured by both biomarkers (p < 0.0001); it was stronger than smoking. C-reactive protein was positively associated with lipid peroxidation (p = 0.004), as was plasma cholesterol. Plasma ascorbic acid had a strong inverse relation (p < 0.001) with both biomarkers. Plasma ß-carotene was also associated with F2-isoprostanes. Other plasma antioxidants were not associated with lipid peroxidation biomarkers, once ascorbic acid was included in the multivariate model. Future surveys and epidemiologic studies should measure at least one marker of oxidative damage, as well as plasma ascorbic acid. These data would permit a better understanding of the role that oxidants and antioxidants play in the health of human populations. Am J Epidemiol 2002;156:274–85.
ascorbic acid; biological markers; C-reactive protein; epidemiology, molecular; lipid peroxidation; obesity; oxidative stress; sex characteristics
Abbreviations: Abbreviations: Iso-P, F2-isoprostane(s); MDA, malondialdehyde; TBARS, thiobarbituric acid reactive substances.
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