Am J Epidemiol 2002; 156:1133-1140.
Copyright © 2002 by Johns
Hopkins Bloomberg School of Public Health
ORIGINAL CONTRIBUTIONS |
Uropathogenic Escherichia coli Are More Likely than Commensal E. coli to Be Shared between Heterosexual Sex Partners
1 Center for Molecular and Clinical Epidemiology, Department of Epidemiology, The University of Michigan School of Public Health, Ann Arbor, MI.
2 Center for Statistical Consultation and Research, University of Michigan, Ann Arbor, MI.
3 Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI.
Because uropathogenic Escherichia coli are better adapted than other E. coli to the urethra, periurethra, and vagina, the authors reasoned that uropathogenic E. coli would be more likely than commensal E. coli to be shared between sex partners. In this 1996–1999 Michigan study, the genetic identity of E. coli isolated from 166 women with E. coli urinary tract infection (UTI) and 94 women without UTI and their sex partners was determined by pulsed-field gel electrophoresis. Rectal isolates were considered uropathogenic E. coli if genetically identical to the urinary isolate causing UTI. All eight urinary isolates from men with UTI partners were identical to the E. coli found in the urine or vagina of their sex partner. When the 550 unique rectal E. coli isolates from couples were considered the unit of analysis, E. coli that caused UTI were nine times (odds ratio (OR) = 8.87, 95% confidence interval (CI): 5.41, 14.54) more likely than other E. coli to be shared between sex partners. Sharing occurred twice as frequently (OR = 1.87, 95% CI: 1.13, 3.08) if the E. coli had P pili or if the couples engaged in oral sex (OR = 2.09, 95% CI: 1.09, 4.00). Uropathogenic E. coli are more likely than commensal E. coli to be shared with a current heterosexual sex partner. Both sexual behaviors and a bacterial virulence factor, P pili, modified sharing.
disease transmission; Escherichia coli; sexual partners; urinary tract infections
Abbreviations: Abbreviations: cfu, colony-forming unit; CI, confidence interval; OR, odds ratio; PFGE, pulsed-field gel electrophoresis; UTI, urinary tract infection.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. R. Johnson, S. Miller, B. Johnston, C. Clabots, and C. DebRoy Sharing of Escherichia coli Sequence Type ST131 and Other Multidrug-Resistant and Urovirulent E. coli Strains among Dogs and Cats within a Household J. Clin. Microbiol., November 1, 2009; 47(11): 3721 - 3725. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Bower, H. B. Gordon-Raagas, and M. A. Mulvey Conditioning of Uropathogenic Escherichia coli for Enhanced Colonization of Host Infect. Immun., May 1, 2009; 77(5): 2104 - 2112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Lobos and C. Padilla Phenotypic characterization and genomic DNA polymorphisms of Escherichia coli strains isolated as the sole micro-organism from vaginal infections Microbiology, March 1, 2009; 155(3): 825 - 830. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. McNamara, U. Srinivasan, L. Zhang, T. S. Whittam, C. F. Marrs, and B. Foxman Comparison of Probe Hybridization Array Typing to Multilocus Sequence Typing for Pathogenic Escherichia coli J. Clin. Microbiol., March 1, 2009; 47(3): 596 - 602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Johnson, C. Clabots, and M. A. Kuskowski Multiple-Host Sharing, Long-Term Persistence, and Virulence of Escherichia coli Clones from Human and Animal Household Members J. Clin. Microbiol., December 1, 2008; 46(12): 4078 - 4082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Rodriguez-Bano, L. Lopez-Cerero, M. D. Navarro, P. D. de Alba, and A. Pascual Faecal carriage of extended-spectrum {beta}-lactamase-producing Escherichia coli: prevalence, risk factors and molecular epidemiology J. Antimicrob. Chemother., November 1, 2008; 62(5): 1142 - 1149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Srinivasan, L. Zhang, A. M. France, D. Ghosh, W. Shalaby, J. Xie, C. F. Marrs, and B. Foxman Probe Hybridization Array Typing: a Binary Typing Method for Escherichia coli J. Clin. Microbiol., January 1, 2007; 45(1): 206 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Xie, B. Foxman, L. Zhang, and C. F. Marrs Molecular Epidemiologic Identification of Escherichia coli Genes That Are Potentially Involved in Movement of the Organism from the Intestinal Tract to the Vagina and Bladder J. Clin. Microbiol., July 1, 2006; 44(7): 2434 - 2441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. D. Solberg, R. M. Ajiboye, and L. W. Riley Origin of Class 1 and 2 Integrons and Gene Cassettes in a Population-Based Sample of Uropathogenic Escherichia coli J. Clin. Microbiol., April 1, 2006; 44(4): 1347 - 1351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rao, S. Hu, L. McHugh, K. Lueders, K. Henry, Q. Zhao, R. A. Fekete, S. Kar, S. Adhya, and D. H. Hamer From the Cover: Toward a live microbial microbicide for HIV: Commensal bacteria secreting an HIV fusion inhibitor peptide PNAS, August 23, 2005; 102(34): 11993 - 11998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Johnson, F. Scheutz, P. Ulleryd, M. A. Kuskowski, T. T. O'Bryan, and T. Sandberg Phylogenetic and Pathotypic Comparison of Concurrent Urine and Rectal Escherichia coli Isolates from Men with Febrile Urinary Tract Infection J. Clin. Microbiol., August 1, 2005; 43(8): 3895 - 3900. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Murray, M. A. Kuskowski, and J. R. Johnson Virulence Factors Predict Escherichia coli Colonization Patterns among Human and Animal Household Members Ann Intern Med, May 18, 2004; 140(10): 848 - 849. [Full Text] [PDF]
|
|
|
|
 |
|
 RE: "UROPATHOGENIC ESCHERICHIA COLI ARE MORE LIKELY THAN COMMENSAL E. COLI TO BE SHARED BETWEEN HETEROSEXUAL SEX PARTNERS" Am. J. Epidemiol., August 15, 2003; 158(4): 396 - 396. [Full Text] [PDF]
|
|