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American Journal of Epidemiology Vol. 155, No. 8 : 771-775
Copyright © 2002 by The Johns Hopkins University School of Hygiene and Public Health

PRACTICE OF EPIDEMIOLOGY

Commentary: Trade-offs in the Development of a Sample Design for Case-Control Studies

Ralph DiGaetano and Joseph Waksberg

From Westat, 1650 Research Boulevard, Rockville, MD 20850-3195 (e-mail: ralphdigaetano{at}westat.com).

The recent article, "Comparison of Telephone Sampling and Area Sampling: Response Rates and Within-Household Coverage" (Am J Epidemiol 2001;153:1119–27), raised a number of issues related to two sampling methodologies that can be used for selecting population-based controls for case-control studies: random digit dialing (RDD) and area probability sampling. Some of these issues are discussed in this commentary in more detail to help in making sample design decisions, including the need to take the analysis plan into account when developing a sample design. Data from the paper are used to illustrate how the choice of sample design can affect analyses. Relative costs associated with the two methodologies as well as variance and bias concerns are also discussed in detail. Sample coverage issues, including those associated with list-assisted RDD, are considered, as are some advantages of the list-assisted approach. A discussion of the use of concurrent screening and sampling with an RDD approach as an alternative to periodically selecting fixed sample sizes is provided.

bias; case-control studies; cluster sampling; data collection; intraclass correlation; random digit dialing; sample design

Abbreviations: APS, area probability sample; RDD, random digit dialing; WISH, Women's Interview Study of Health


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