American Journal of Epidemiology Vol. 155, No. 5 : 463-471
Copyright © 2002 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Lung Function in Relation to Intake of Carotenoids and Other Antioxidant Vitamins in a Population-based Study
1 Department of Medicine, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY.
2 Department of Social and Preventive Medicine, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY.
3 Section of Pulmonary, Critical Care, and Sleep Medicine, Veterans Administration Medical Center, Buffalo, NY.
Accumulating evidence suggests that dietary antioxidant vitamins are positively associated with lung function. No evidence exists regarding whether dietary carotenoids other than ß-carotene are related to pulmonary function. In 1995–1998 the authors studied the association of forced expiratory volume in 1 second and forced vital capacity as the percentage of the predicted value (FEV1% and FVC%, respectively) after adjustment for height, age, gender, and race with the intakes of several carotenoids (
-carotene, ß-carotene, ß-cryptoxanthin, lutein/zeaxanthin, and lycopene) in a random sample of 1,616 men and women who were residents of western New York State, aged 35–79 years, and free from respiratory disease. They observed significant associations of lutein/zeaxanthin and vitamins C and E with FEV1% and FVC% using multiple linear regression after adjustment for total energy intake, smoking, and other covariates. When they analyzed all of these antioxidant vitamins simultaneously, they observed the strongest association of vitamin E with FEV1% and of lutein/zeaxanthin with FVC%. The differences in forced expiratory volume in 1 second and forced vital capacity associated with a decrease of 1 standard deviation of dietary vitamin E or lutein/zeaxanthin were equivalent to the influence of approximately 1–2 years of aging. Their findings support the hypothesis that carotenoids, vitamin C, and vitamin E may play a role in respiratory health and that carotenoids other than ß-carotene may be involved.
airway obstruction; antioxidants; carotenoids; lung diseases, obstructive; oxidants; oxidative stress; respiratory function tests; vitamins
Abbreviations: FEV1, forced expiratory volume in 1 second; FEV1%, forced expiratory volume in 1 second as the percentage of the predicted value; FVC, forced vital capacity; FVC%, forced vital capacity as the percentage of the predicted value; NHANES III, Third National Health and Nutrition Examination Survey
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