American Journal of Epidemiology Vol. 155, No. 4 : 323-331
Copyright © 2002 by The Johns Hopkins University School of Hygiene and Public Health
ORIGINAL CONTRIBUTIONS |
Alcohol and Hepatocellular Carcinoma: The Effect of Lifetime Intake and Hepatitis Virus Infections in Men and Women
1 Cattedra di Igiene, Università di Brescia, Brescia, Italy.
2 Istituto di Virologia, Università di Milano, Milano, Italy.
3 Cattedra di Statistica Medica, Università di Brescia, Brescia, Italy.
4 International Agency for Research on Cancer, Lyon, France.
5 Cattedra di Igiene, Università di Milano, Milano, Italy.
6 Cattedra di Medicina del Lavoro, Università di Brescia, Brescia, Italy.
The authors investigated the dose-effect relation between alcohol drinking and hepatocellular carcinoma (HCC) in men and women separately, also considering hepatitis B and hepatitis C virus infections. They enrolled 464 subjects (380 men) with a first diagnosis of HCC as cases and 824 subjects (686 men) unaffected by hepatic diseases as controls; all were hospitalized in Brescia, northern Italy, in 1995–2000. Spline regression models showed a steady linear increase in the odds ratio of HCC for increasing alcohol intake, for values of >60 g of ethanol per day, with no substantial differences between men and women. Duration of drinking and age at start had no effect on the odds ratio when alcohol intake was considered. Former drinkers who had stopped 1–10 years previously had a higher risk of HCC than current drinkers did. The effect of alcohol drinking was evident even in the absence of hepatitis B or hepatitis C virus infection. In addition, a synergism between alcohol drinking and either infection was found, with approximately a twofold increase in the odds ratio for each hepatitis virus infection for drinkers of >60 g per day.
alcohol drinking; carcinoma, hepatocellular; case-control studies; hepatitis B virus; hepatitis C-like viruses; odds ratio; risk factors
Abbreviations: HBsAg, hepatitis B surface antigen; HCC, hepatocellular carcinoma; OR, odds ratio
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  N. Portolani, G. L. Baiocchi, A. Coniglio, T. Piardi, L. Grazioli, A. Benetti, A. F. Bravo, and S. M. Giulini Intrahepatic Cholangiocarcinoma and Combined Hepatocellular-Cholangiocarcinoma: A Western Experience Ann. Surg. Oncol., July 1, 2008; 15(7): 1880 - 1890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Ohishi, S. Fujiwara, J. B. Cologne, G. Suzuki, M. Akahoshi, N. Nishi, I. Takahashi, and K. Chayama Risk Factors for Hepatocellular Carcinoma in a Japanese Population: A Nested Case-Control Study Cancer Epidemiol. Biomarkers Prev., April 1, 2008; 17(4): 846 - 854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Franceschi, M. Montella, J. Polesel, C. La Vecchia, A. Crispo, L. Dal Maso, P. Casarin, F. Izzo, L. G. Tommasi, I. Chemin, et al. Hepatitis viruses, alcohol, and tobacco in the etiology of hepatocellular carcinoma in Italy. Cancer Epidemiol. Biomarkers Prev., April 1, 2006; 15(4): 683 - 689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Schottenfeld and J. Beebe-Dimmer Chronic inflammation: a common and important factor in the pathogenesis of neoplasia. CA Cancer J Clin, March 1, 2006; 56(2): 69 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V Lo Re III and J R Kostman Management of chronic hepatitis C Postgrad. Med. J., June 1, 2005; 81(956): 376 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Aldridge, J. A. Gibbons, M. M. Flaherty, M. L. Kreider, J. A. Romano, and E. D. Levin Heterogeneity of Toxicant Response: Sources of Human Variability Toxicol. Sci., November 1, 2003; 76(1): 3 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Santagostino, M. Colombo, M. Rivi, M. G. Rumi, A. Rocino, S. Linari, and P. M. Mannucci A 6-month versus a 12-month surveillance for hepatocellular carcinoma in 559 hemophiliacs infected with the hepatitis C virus Blood, July 1, 2003; 102(1): 78 - 82. [Abstract] [Full Text] [PDF]
|
|